中医药治疗肠道菌群失调症的方剂用药规律分析  

Prescription Principles of Traditional Chinese Medicines for Treating Intestinal Flora Alteration

作　　者：安婉丽 李雪丽[1] 孔冉[1] 邸莎[1] 杨鸿[1] AN Wan-li;LI Xue-li;KONG Ran;DI Sha;YANG Hong(Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China)

机构地区：[1]中国中医科学院医学实验中心

出　　处：《中国实验方剂学杂志》2018年第12期210-215,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市中医药科技项目(Z161100001816003)

摘　　要：目的：基于中医传承辅助系统软件,分析和总结1995—2016年中医药治疗肠道菌群失调症的用药规律,并根据用药规律对新方做出预测。方法：收集中国全文期刊数据库（CNKI）中治疗肠道菌群失调症有效的中医药方剂相关文献,运用中医传承辅助系统软件建立方剂数据库,对用药规律进行统计分析。结果：筛选治疗肠道菌群失调症的方剂148篇,分析得到治疗肠道菌群失调症的32味常用药物,7种常用药对用药模式,16个新方核心组合以及8个新处方。结论：分析显示治疗肠道菌群失调症的药物主要以补气健脾、渗湿利水类药物为常见。通过聚类分析得到的新方,与临床上治疗肠道菌群失调症常用方剂参苓白术散、补中益气汤和健脾渗湿汤等有相似的治疗作用,但同时又参以理气疏肝之药物,以达到舒达肝气、健补脾胃的作用。配伍组合符合补气健脾、渗湿止泻等临床主要治疗思路,有利于指导临床实践,为临床新药的开发和利用奠定的一定的基础。Objective： To analyze and summarize the prescription principles of traditional Chinese medicine（ TCM） for treating intestinal flora alteration during 1995—2016 by using TCM Inheritance Support System,and make predictions of new formulations according to the composing principles. Method： Related papers on TCM prescriptions for treating intestinal flora alteration were collected from China national knowledge infrastructure（ CNKI）,and then TCM Inheritance Support System was used to establish the prescription database and analyze the composing principles of herbs in the prescriptions. Result： Totally 148 papers on the prescriptions for treating intestinal flora alteration were screened to achieve 32 commonly used herbs,7 common composing principles,16 core combinations of new prescriptions and 8 new prescriptions. Conclusion： Analysis shows that the drugs for intestinal flora alteration are mainly those for regulating spleen and stomach,eliminating dampness and alleviating water retention. The new prescriptions obtained by cluster analysis have similar treatment effect with the common prescriptions,such as Shenling Baizhu San,Buzhong Yiqitang,Jianpi Shenshitang,for intestinal flora alteration,but the new prescriptions,also have the herbs with regulating Qi and relieving liver functions to achieve the effects of regulating liver and Qi as well as tonifying the spleen and stomach. Compatibility combination conforms to the main clinical treatment ideas of invigorating Qi and tonifying spleen,excreting dampness and reducing diarrhea,helpful to guide clinical practice,and providing certain basis for clinical development and use of new drugs.

关 键 词：肠道菌群失调症 中医传承辅助系统 组方规律 药对 用药模式 

分 类 号：R24[医药卫生—中医临床基础] R22[医药卫生—中医学]