脊髓损伤动物模型的研究现状  

Current research on animal model of spinal cord injury: a review of the literature

作　　者：齐英娜 谭明生[1] QI Ying-na;TAN Ming-sheng(Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.)

机构地区：[1]中日友好医院脊柱外科,北京100029 [2]北京中医药大学,北京100029

出　　处：《中国矫形外科杂志》2018年第10期927-929,共3页Orthopedic Journal of China

摘　　要：脊髓损伤(spinal cord injury,SCI)的发病率逐年上升,SCI中,不完全性SCI发病百分比和上颈SCI发病百分比逐年上升,完全性SCI发病百分比和下颈SCI发病百分比下降。目前研究发现手术减压安全有效,尽管SCI后手术干预方式和最佳时间存在争议。完全性SCI和不完全性SCI神经功能恢复程度不同,且研究发现减压时间影响SCI术中、术后并发症的发生率和死亡率。部分研究证实早期减压可减少并发症和死亡率,但仍缺乏严格的临床随机对照实验研究。因而建立具有良好临床相关性、可重复性、可调控性、可规范化操作的动物模型尤为重要。本文拟从以下2个问题进行综述:(1)急性SCI动物模型种类及优缺点;(2)慢性SCI动物模型种类及优缺点。The morbidity of spinal cord injury（SCI） has obviously gone up in recent years, especially the incomplete SCI and upper cervical SCI. Current researches show that surgical decompression is safe and effective intervention, although the best time for intervention is still controversial. After surgical treatment, the complete SCI and incomplete SCI are considerably different in neurological functional recovery. Some studies revealed that early decompression might related to significant decrease of complication incidence and mortality. However rigorous clinical randomized controlled trials are still needed to provide convincing evidences for clinical practices. Therefore, it is important to establish an SCI animal model with good clinical relevance, reproducibility, and regulation. This paper intends to introduce advantages and disadvantages of acute and chronic SCI animal models respectively

关 键 词：脊髓损伤 动物模型 综述 

分 类 号：R683.2[医药卫生—骨科学]