昂丹司琼联合右美托咪定防治剖宫产术中卡前列素氨丁三醇不良反应临床观察  

Effect of ondansetron and dexmedetomidine on preventing the adverse reactions of carboprost tromethmine in caesarean section

作　　者：李瑞霞[1] 王丽 LI Rui-xia;WANG Li(Department of Anesthesia, the Third People＇s Hospital of Jinan, Jinan 250000, Chin)

机构地区：[1]济南市第三人民医院麻醉科,250000 [2]山东省妇幼保健院麻醉科,济南250000

出　　处：《中华实用诊断与治疗杂志》2018年第6期607-609,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金资助项目(No.81273821)

摘　　要：目的探讨昂丹司琼联合右美托咪定预防剖宫产术中卡前列素氨丁三醇不良反应的效果。方法择期行子宫下段剖宫产术产妇120例,随机分为昂丹司琼组、昂丹司琼+右美托咪定组(联合组)和对照组,每组40例,于子宫体肌注卡前列素氨丁三醇250μg后,昂丹司琼组静脉注射昂丹司琼8mg,联合组静脉注射昂丹司琼8mg+静脉泵入负荷量0.5μg/kg右美托咪定,对照组静脉注射及静脉泵入等体积生理盐水。记录产妇年龄、体质量、孕周、手术时间、术中出血量及输液量,记录使用卡前列腺素氨丁三醇至手术结束产妇胸闷、面部潮红、恶心和/或呕吐、高血压及心动过速不良反应发生情况,以及手术结束时Ramsay镇静评分,并进行组间比较。结果 3组年龄、体质量、孕周、手术时间、术中出血量及输液量比较差异均无统计学意义(P>0.05);联合组胸闷(7.5%)、面部潮红(7.5%)、高血压(2.5%)和心动过速(2.5%)发生率均低于对照组(37.5%、55.0%、22.5%、52.5%)和昂丹司琼组(30.0%、37.5%、10.0%、42.5%)(P<0.05),昂丹司琼组与对照组比较差异均无统计学意义(P>0.05);联合组、昂丹司琼组恶心和/或呕吐发生率(5.0%、7.5%)低于对照组(42.5%)(P<0.05),昂丹司琼组与联合组比较差异均无统计学意义(P>0.05);联合组Ramsay镇静评分(3.47±0.68)高于昂丹司琼组(1.37±0.49)和对照组(1.10±0.31)(P<0.05),昂丹司琼组Ramsay镇静评分与对照组比较差异无统计学意义(P>0.05)。结论昂丹司琼联合右美托咪定可有效防治剖宫产术中卡前列素氨丁三醇引起的不良反应。Objective To observe the clinical effect of ondansetron and dexmedetomidine on preventing the adverse reactions of carboprost tromethmine in patients undergoing caesarean section.Methods Totally 120 pregnant women scheduled for elective caesarean section were randomly divided into ondansetron group,combined group receiving ondansetron and dexmedetomidine and control group,with 40 patients in each group.After injecting carboprost tromethmine 250μg into myometrium,ondansetron group received intravenous injection of ondansetron 8 mg,combined group received intravenous injection of ondansetron 8 mg ＋ intravenous pumping of dexmedetomidine 0.5μg/kg,and control group received equivalent volume of normal saline.The age,body mass,gestational week,operation lasting time,intraoperative blood loss and infusion volume were recorded.The adverse reactions such as dyspnea,facial flushing,nausea and/or vomiting,hypertension and tachycardia were observed,and the Ramsay scores were also recorded at the end of surgery,and compared among groups.Results There were no significant differences in the age,body mass,gestational week,operation lasting time,intraoperative blood loss and infusion volume among three groups（P〉0.05）.In combined group,the incidences of dyspnea（7.5%）,facial flushing（7.5%）,hypertension（2.5%）and tachycardia（2.5%）were significantly lower than those in control group（37.5%,55.0%,22.5%,52.5%）and ondansetron group（30.0%,37.5%,10.0%,42.5%）（P〈0.05）,and there were no significant differences between ondansetron group and control group（P〉0.05）.The incidence of nausea and/or vomiting was significantly lower in combined group（5.0%）and ondansetron group（7.5%）than that in control group（42.5%）（P〈0.05）.The Ramsay score was significantly higher in combined group（3.47±0.68）than that in ondansetron group（1.37±0.49）and control group（1.10±0.31）（P〈0.05）,and there was no significant difference between ondansetron group and control group（P〉0.05）.Con

关 键 词：剖宫产术 右美托咪定 昂丹司琼 卡前列素氨丁三醇 不良反应 

分 类 号：R614[医药卫生—麻醉学]