气候变化对主动脉夹层发生的影响  

Impact of climate change on aortic dissection onset

作　　者：丘俊涛 于存涛[1] 罗新锦[1] 杨军 刘燊[1] 姜文翔 张良[1] QIU Juntao;YU Cuntao;LUO Xinjin;YANG Jun;LIU Shen;JIANG Wenxiang;ZHANG Liang(Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, P.R.China;Institute for Environmental and Climate Research, Jinan University, Guangzhou, 510632, P.R.China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院心外科,北京100037 [2]暨南大学环境与气候研究院,广州510632

出　　处：《中国胸心血管外科临床杂志》2018年第6期482-488,共7页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金项目(81270385);中国医学科学院创新工程大血管疾病发病机制及干预研究(2016I2M1016)

摘　　要：目的研究气侯变化对主动脉夹层发生的影响,为主动脉夹层的预测和预防提供思路。方法收集2010年1月1日至2016年12月31日阜外医院收治来自河北省的所有急性主动脉夹层患者临床资料,与河北省每月气象数据,利用广义模型探索气候变化与主动脉夹层发病的关系。结果阜外医院6年期间共接诊来自河北省急性主动脉夹层患者1 121例,男873例、女248例,平均年龄(51.4±12.0)岁。通过单因素分析发现温度、湿度、气压差异均有统计学意义(P<0.01),进一步通过多因素分析发现温度与主动脉夹层的发生相关(P<0.01)。最低温度对主动脉夹层的发生具有最佳预测作用,相对危险度为1.02,95%置信区间为(1.02,1.03)。结论气候条件的变化会影响主动脉夹层的发生,低温是引起主动脉夹层发病的重要触发因素。Objective To explore impact of climate change on aortic dissection and to put forward a new way about prediction and prevention of aortic dissection. Methods We retrospectively analyzed the characteristics of acute aortic dissection patients came from Hebei province in Fuwai Hospital between 2010 and 2016 year. Meanwhile, we collected monthly maximum temperature, minimum temperature, average temperature, average pressure, amount of rainfall, sunshine, humidity and other meteorological data. Generalized model was implied to explore climate change and the incidence of aortic dissection. Results A total of 1 121 acute aortic dissection patients from Hebei province were admitted in Fuwai Hospital during the period of 6 years. There were 774 patients were type A aortic dissection, and 347 patients were type B aortic dissection. The average age was 51.4±12.0 years. There were 873 males and 248 females. There were 889 （79.3%） patients with hypertension, 99 （8.83%） with Marfan syndrome. It was found that temperature, humidity and air pressure were all statistically significant for indication aortic dissection through single variable analysis （P〈0.01）. The temperature was only variable by one-way analysis of variance （P〈0.01）. The lowest temperature has the best predictive effect on the occurrence of aortic dissection. The relative risk was 1.02 with 95% confidence interval 1.02 to 1.03. Conclusion The change of climatic conditions can affect the occurrence of aortic dissection, and the lowest temperature is an important trigger factor for aortic dissection onset.

关 键 词：主动脉夹层 气候 发病率 气温 气压 

分 类 号：R543.1[医药卫生—心血管疾病]