纳秒脉冲电场灭菌对益母草膏中盐酸水苏碱含量及小鼠肝脏毒性影响  

Effect of Nanosecond Pulsed Electric Field Sterilization on the Content of Stachydrine Hydrochloride in the Motherwort Cream and the Liver Toxity in Mice

作　　者：陈新梅[1] 陈永刚 薛文静 CHEN Xinmei;CHEN Yonggang;XUE Wenjing(Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China;Hangzhou Ridi Biological Technology Co., Ltd., Hangzhou 311121, Zhejiang, China;Xinjiang Nanosecond Technology Application Research Institute, Urumuqi 830026, Xinjiang, China;Qingdao Institute of Drug Control, Qingdao 266071, Shandong, China)

机构地区：[1]山东中医药大学,山东济南250355 [2]杭州睿笛生物科技有限公司,浙江杭州311121 [3]新疆纳秒技术应用研究所,新疆乌鲁木齐830026 [4]青岛市药品检验所,山东青岛266071

出　　处：《辽宁中医药大学学报》2018年第5期27-30,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2015-017)

摘　　要：目的：考察纳秒脉冲电场灭菌对益母草膏中盐酸水苏碱的含量和小鼠肝脏毒性的影响。方法：采用纳秒脉冲电场对益母草膏进行灭菌,用HPLC-UV和氨基柱测定盐酸水苏碱的含量,考察小鼠肝脏的毒性。结果：灭菌前后益母草中的盐酸水苏碱含量分别为78.58、77.92μg,对小鼠肝脏无毒性。结论：纳秒脉冲电场灭菌法对益母草膏中盐酸水苏碱的含量无影响、对肝脏无毒性。Objective ：To explore the effect of nanosecond pulsed electric field sterilization of stachydrine hydrochloride in motherwort cream and the liver toxity in mice. Methods ：Motherwort cream was sterilization by nanosecond pulsed electric filed. The content of stachydrine hydrochloride was determined by HPLC-UV and amino column. The liver toxiciy in mice was investigated. Results ：The conten of stachydrine hydrochloride was 78.58 and 77.92 μg before and after sterilization. It had no liver toxity to mice. Conclusion ：Nanosecond pulsed electric field sterilization had no effect on the content of stachydrine hydrochloride and had no liver toxicity.

关 键 词：纳秒脉冲电场 灭菌 益母草膏 盐酸水苏碱 肝脏毒性 

分 类 号：R284.2[医药卫生—中药学]