水通道蛋白1在肿瘤进展中的作用及其抑制剂研究进展  

Inhibitors of aquaporin 1 and its role in tumor development and progression

作　　者：张智昱 武娟 李学军[1] ZHANG Zhi-yu;WU Juan;LI Xue-jun(School of Basic Medical Science, Health Science Center, Peking University, Beijing 100191, China)

机构地区：[1]北京大学医学部基础医学院,北京100191

出　　处：《药学学报》2018年第6期910-919,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81473235)

摘　　要：水通道蛋白1(AQP1)是细胞膜上的疏水跨膜蛋白,能够介导水分子的跨膜转运,同时也是AQP家族中第一个被发现的水通道蛋白。研究表明,AQP1在肿瘤细胞增殖迁移、血管生成及肿瘤的发展和演进中发挥作用,或许将成为潜在的肿瘤治疗靶点。本文将主要从AQP1的结构功能、在肿瘤进展中的作用及其抑制剂等方面进行综述。Aquaporin 1 （AQP1）, the first water channel protein discovered among the aquaporin family, is a hydrophobic transmembrane protein involved in transcellular water movement. Recent evidence shows that AQP1 plays a role in tumor cell proliferation and migration, angiogenesis and tumor development and progression, representing a potential therapeutic target. In this review, we discuss the structures, functions and inhibitors ofAQP1, as well as the involvement of AQP1 in tumor development and progression.

关 键 词：水通道蛋白1 肿瘤增殖 肿瘤细胞迁移 血管生成 抑制剂 

分 类 号：R966[医药卫生—药理学]