Chiral Phase-transfer Catalysts Bearing Multiple Hydrogen-bonding Donors Derived from Amino Acids： Efficient Catalysts for Diastereo- and Enantioselective Nitro-Mannich Reaction  

作　　者：LIU Yu WEI Zhonglin LIU Yuxin WANG Jingdong CAO Jungang LIANG Dapeng DUAN Haifeng LIN Yingjie 

机构地区：[1]College of Chemistry, Jilin University, Changehun 130012, P. R. China

出　　处：《Chemical Research in Chinese Universities》2018年第3期333-337,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No. 51373067）.

摘　　要：The asymmetric nitro-Mannich reaction is one of the traditional methods for forming carbon-carbon bond. By this reaction, the corresponding products with two contiguous stereocenters containing nitrogen substituents can be obtained. These β-nitro amine products can be easily transformed into 1,2-diamines by reduction of the corresponding nitro groups by means of the Nef reaction. It is well known that chiral 1,2-diamines Nay an important role in many fields.The asymmetric nitro-Mannich reaction is one of the traditional methods for forming carbon-carbon bond. By this reaction, the corresponding products with two contiguous stereocenters containing nitrogen substituents can be obtained. These β-nitro amine products can be easily transformed into 1,2-diamines by reduction of the corresponding nitro groups by means of the Nef reaction. It is well known that chiral 1,2-diamines Nay an important role in many fields.

关 键 词：Multiple hydrogen-bonding Phase-transfer catalyst Nitro-Mannich reaction Aldehyde-derived N-Bocketimine 

分 类 号：O643.36[理学—物理化学] TQ028.8[理学—化学]