三七总皂苷与细胞色素P450酶相互作用的研究进展  

Progress in the study of the interaction between panax notoginseng saponins and cytochrome P450 enzymes

作　　者：余绪明 刘艳红 骆霞 王佳 余世荣 YU Xu-ming;LIU Yan-hong;LUO Xia;WANG Jia;YU Shi-rong(Department of Pharmacy, Renmin Hospital Hubei University of Medicine, Hubei Shiyan 442000, Chin)

机构地区：[1]湖北医药学院附属人民医院药学部,湖北十堰442000

出　　处：《临床药物治疗杂志》2018年第4期40-43,共4页Clinical Medication Journal

摘　　要：临床上三七总皂苷广泛应用于心脑血管疾病的治疗,随着其应用范围不断扩大,不良反应也逐渐增多。三七总皂苷对细胞色素P450的诱导或抑制作用,可引起临床上药物代谢性相互作用,当联合其他药物使用时,可能会引起不良反应或者治疗失败。本文就三七总皂苷对肝脏细胞色素P450活性的影响做一综述,以期为临床安全、有效、合理的使用三七总皂苷,减少药物联用时的不良反应提供指导。Panax notoginseng saponins（PNS） have been widely used in the treatment of cardiovascular and cerebrovascular diseases in clinical settings. With the continuous expansion of its application, adverse reactions were gradually increased. The induction or inhibition of cytochrome P450 by PNS can cause clinical drug interactions. When used in combination with other drugs, it may cause adverse reactions or treatment failure. This article reviewed the effects of PNS on the activity of liver cytochrome P450 in order to provide guidance for safe, effective and rational use of PNS, and reduce the adverse reactions in the combination of drugs.

关 键 词：三七总皂苷 CYPS 代谢性相互作用 ADR 

分 类 号：R969.2[医药卫生—药理学]