氯雷他定联合法莫替丁治疗嗜酸性粒细胞性胃肠炎的临床研究  

Clinical study on loratadine combined with famotidine in treatment of eosinophilic gastroenteritis

作　　者：孟明明 刘红[1] 王沧海[1] 宿慧[1] 刘揆亮[1] 余春开 吴静[1] MENG Ming-ming;LIU Hong;WANG Cang-hai;SU Hui;LIU Kui-liang;YU Chun-kai;WU Jing(Department of Gastroenterology, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China)

机构地区：[1]首都医科大学附属北京世纪坛医院消化内科,北京100038

出　　处：《现代药物与临床》2018年第5期1072-1075,共4页Drugs & Clinic

摘　　要：目的探讨氯雷他定联合法莫替丁治疗嗜酸性粒细胞性胃肠炎的临床疗效。方法选取2016年12月—2017年12月首都医科大学附属北京世纪坛医院收治的嗜酸性粒细胞性胃肠炎的患者42例,随机分为对照组和治疗组,每组各21例。对照组餐前口服法莫替丁片,20 mg/次,2次/d。治疗组在对照组治疗基础上口服氯雷他定片,10 mg/次,1次/d。两组均连续治疗8周。观察两组的临床疗效,比较两组治疗前后血嗜酸粒细胞计数、组织嗜酸粒细胞计数、Ig E水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别为80.95%和95.23%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者血嗜酸粒细胞计数、组织嗜酸粒细胞计数、Ig E水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组血嗜酸粒细胞计数、组织嗜酸粒细胞计数、Ig E水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论氯雷他定联合法莫替丁治疗嗜酸性粒细胞性胃肠炎具有较好的临床疗效,降低患者外周血及组织中嗜酸性粒细胞水平,具有一定的临床推广应用价值。Objective To investigate the clinical effect of loratadine combined with famotidine in treatment of eosinophilic gastroenteritis. Methods Patients（42 cases） with eosinophilic gastroenteritis in Beijing Shijitan Hospital Affiliated Capital Medical University from December 2016 to December 2017 were randomly divided into control（21 cases） and treatment（21 cases） groups. Patients in the control group were po administered with Famotidine Tablets before meal, 20 mg/time, twice daily. Patients in the treatment group were po administered with Loratadine Tablets on the basis of the control group, 10 mg/time, once daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the blood eosinophil count, tissue eosinophil count and Ig E level in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.95% and 95.23%, and there were differences between two groups（P〈0.05）. After treatment, blood eosinophil count, tissue eosinophil count and Ig E level in two groups were significantly decreased, and there were differences in the same group（P〈0.05）. After treatment, blood eosinophil count, tissue eosinophil count and Ig E level in the treatment group were lower than those in the control group, and there were differences between two groups（P〈0.05）. Conclusion Loratadine combined with famotidine has significant clinical effect in treatment of eosinophilic gastroenteritis, and can reduce the level of eosinophils in peripheral blood and tissues, which has a certain clinical application value.

关 键 词：氯雷他定片 法莫替丁片 嗜酸性粒细胞性胃肠炎 嗜酸粒细胞 IgE 

分 类 号：R975[医药卫生—药品]