葛根素注射液联合多奈哌齐治疗帕金森病的疗效观察  

Clinical observation of Puerarin Injection combined with donepezil in treatment of Parkinson's disease

作　　者：顾亮亮[1] 付国惠[1] 张保朝[1] 邢娟[1] GU Liang-liang;FU Guo-hui;ZHANG Bao-chao;XING Juan(Department of Neurology, Nanyang City Central Hospital, Nanyang 473000, Chin)

机构地区：[1]南阳市中心医院神经内科,河南南阳473000

出　　处：《现代药物与临床》2018年第5期1230-1233,共4页Drugs & Clinic

摘　　要：目的探讨葛根素注射液联合盐酸多奈哌齐片治疗帕金森病的临床疗效。方法选取2016年2月—2017年12月南阳市中心医院收治的帕金森病患者98例为研究对象,所有患者随机分为对照组和治疗组,每组各49例。对照组患者睡前口服盐酸多奈哌齐片,1片/次,1次/d,维持1个月,然后根据治疗效果增加剂量至2片/次,1片/d。治疗组在对照组基础上静脉滴注葛根素注射液,400 mg加入到5%葡萄糖溶液500 m L中,1次/d。15 d为1个疗程,两组患者连续治疗3个疗程。观察两组的临床疗效,比较两组的改良Webster症状评分。结果治疗后,对照组和治疗组的总有效率分别为79.59%、91.83%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者改良Webster症状评分均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者改良Webster症状评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论葛根素注射液联合盐酸多奈哌齐片治疗帕金森病具有较好的临床疗效,可改善临床症状,安全性较好,具有一定的临床推广应用价值。Objective To investigate the clinical effect of Puerarin Injection combined with Donepezil Hydrochloride Tablets in treatment of Parkinson＇s disease. Methods Patients（98 cases） with Parkinson＇s disease in Nanyang City Central Hospital from February 2016 to December 2017 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Donepezil Hydrochloride Tablets at bedtime, 1 tablet/time, once daily, treated for 1 month, then dosage changed to 2 tablets/time, once daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 400 g added into 5% glucose solution 500 m L, once daily. One course was 15 d, and patients in two groups were treated for 3 courses. After treatment, the clinical efficacies were evaluated, and improved Webster symptom scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.59% and 91.83%, respectively, and there was difference between two groups（P〈0.05）. After treatment, improved Webster symptom scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And improved Webster symptom scores in the treatment group was significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Puerarin Injection combined with Donepezil Hydrochloride Tablets has clinical curative effect in treatment of Parkinson＇s disease, can improve clinical symptoms, with good safety, which has a certain clinical application value.

关 键 词：葛根素注射液 盐酸多奈哌齐片 帕金森病 改良Webster症状评分 

分 类 号：R971[医药卫生—药品]