维生素D受体基因多态性与中国汉族人群2型糖尿病肾脏病相关性meta分析  

Correlation meta-analysis of vitamin D receptor gene polymorphisms and susceptibility to type 2 diabetic kidney disease in Chinese Han population

作　　者：赵雪千 宋欣 张永[1] 张庆红[1] 史秀岩[1] 肖厚勤 ZHAO Xue-qian;SONG Xin;ZHANG Yong;ZHANG Qing-hong;SHI Xiu-yan;XIAO Hou-qin(Taihe Hosipital, Hubei University of Medicine, Shiyan 442000, Hubei, Chin)

机构地区：[1]湖北医药学院附属十堰市太和医院,湖北十堰442000

出　　处：《生物医学工程与临床》2018年第3期320-326,共7页Biomedical Engineering and Clinical Medicine

基　　金：国家自然科学基金资助项目(81470950);湖北省自然科学基金资助项目(2014CFB153)

摘　　要：目的对维生素D受体(VDR)基因多态性与中国汉族人群2型糖尿病肾脏病(T2DKD)相关性的研究进行系统评价。方法选择外文期刊数据库(Pub Med,Science Citation Index,Cochrane)及中文期刊数据库(中国知网、万方数据库、维普)。根据系统评价的原理及规范,英文检索词:diabetic nephropathy or diabetic kidney disease or diabetic complication;vitamin D receptor or VDR;polymorphism or single nucleotid polymorphism or variant。中文检索词:糖尿病肾脏病、维生素D受体、基因多态性。检索时间为建立数据库时间至2017年6月。检索有关VDR基因(ApaⅠ、BsmⅠ、FokⅠ、TaqⅠ酶切位点)多态性与中国汉族人群T2DKD相关性的病例对照研究,同时检索纳入文献的参考文献以扩大检索范围。对最终确定符合标准的文献采用Stata 12.0版软件进行meta分析。结果共纳入7篇文献,包含1 496例患者。meta分析结果显示,VDR基因位点ApaⅠ、FokⅠ、TaqⅠ多态性与中国汉族人群T2DKD无明显相关性(P>0.05)。BsmⅠ基因多态性与中国汉族人群T2DKD发生存在关联,等位基因B vs b,比值比(OR)=1.86,95%可信区间(CI)=1.31-2.65,P=0.001,差异有统计学意义;基因型BB+Bb vs bb,OR=2.02,95%CI=1.38-2.96,P=0.000,差异有统计学意义。结论 VDR基因位点BsmⅠ多态性与中国汉族人群T2DKD易感性相关,B等位基因及BB+Bb基因型可能是其T2DKD危险因素。Objective To study the correlation between vitamin D receptor（VDR） gene polymorphisms and susceptibility for type 2 diabetic kidney disease（T2DKD） in Chinese Han population. Methods Relevant studies in online English database（Pubmed, Science Citation Index, Cochrane） and Chinese database（Chinese National Knowledge Infrastructure, Chinese Wanfang, VIP ） updated to June 2017 were collected. By principles and norms of systematic reviews, search in English database was conducted by key words diabetic nephropathy or diabetic kidney disease or diabetic complication, vitamin D receptor or VDR; polymor- pbism or single nucleotid polymorphism or variant. Chinese database search was carried out by key words diabetic nephropa- thy, vitamin D receptor, gene polymorphism. The case-control study on the correlation between polymorphisms of VDR gene （Apa I , Bsm I , Fok 1 , Taq I ） and T2DKD in Chinese Han population was conducted. The references included the retrieved articles to broaden the search range. Stata 12.0 software was used to meta-analysis of the final identified criteria. Results Seven references of 1 496 subjects were recruited. The meta-analysis results showed that the Apa I , Fok I, Taq I polymor- phisms of VDR gene locus had no significant correlation with T2DKD in Chinese Han population（P 〉 0.05）. Bsm 1 gene poly- morphism was associated with T2DKD in Chinese Han population, and the allele B vs b, odds ratio（OR） = 1.86, 95 % confident intervals（CI） = 1.31 - 2.65, P = 0.001, the difference was statistically significant. The genotype BB ＋ Bb vs bb, OR = 2.02, 95 % CI = 1.38 - 2.96, P = 0.000, and the difference was statistically significant. Conclusion It is demonstrated that in Chinese Han population, Bsm I variants might related to T2DKD susceptibility, B allele and BB ＋ Bb genotype of Bsm I variant might be the risk factors for T2DKD.

关 键 词：维生素D受体 2型糖尿病 糖尿病肾脏病 单核苷酸多态性 META分析 

分 类 号：R587.2[医药卫生—内分泌] R393[医药卫生—内科学]