测量葡萄糖浓度的光学低相干干涉法  

The measurement of the concentration of glucose solution by using optical low coherence interferometry

作　　者：张浩[1] 陈明惠[1] 李振洋[1] 王成[1] 郑刚[1] ZHANG Hao;CHEN Minghui;LI Zhenyang;WANG Cheng;ZHENG Gang(Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, Shanghai 200093, Chin)

机构地区：[1]上海理工大学教育部微创医疗器械工程研究中心

出　　处：《光学技术》2018年第3期287-290,共4页Optical Technique

基　　金：国家自然科学基金青年科学基金资助项目(61308115);上海市自然科学基金资助项目(13ZR1457900);上海市科委产学研医资助项目(15DZ1940400)

摘　　要：根据溶液中溶质的浓度变化将引起溶液折射率变化的特性,提出一种利用光学低相干干涉技术通过测量葡萄糖溶液的折射率来确定其浓度的方法。基于迈克尔逊干涉仪,建立了低相干光葡萄糖浓度检测系统,通过调节可移动角镜以产生干涉信号,根据角镜的位移量计算出光程,并进而求出折射率。实验结果表明：在LED光源光谱半高宽度为25nm,可移动角镜的移动步长为微米量级时,利用该方法对折射率的测量精度可以达到10-4数量级以上,对应的可以检测出低于100mg/d L的葡萄糖的浓度变化。过程方便快捷,受外界限制因素小,是一种有效的测量各种液体折射率及浓度的方法。The change of the concentration in solution will cause the change of refractive index of the solution. In this paper,the optical low coherence technology is used to measure the refractive index of glucose solution,and then the concentration of glucose solution can be determined from the refractive index. Putting the solution into the measuring optical path,the optical path length difference can be measured from the interference signals obtained from the photodetector,and then the refractive index of the glucose solution and concentration can be calculated. The experimental results show that the refractive index measurement precision can reach 10-4 orders of magnitude,when the LED light source is used with the Full Width at Half Maximum（ FWHM） of25 nanometers and the portable corner mirror is used with micron moving step. Using the method the glucose concentrations of less than 100 mg/d L can also be measured. The process is convenient and small restricted by external factors. And the effective method can be applied to measure liquid refractive index and concentration.

关 键 词：折射率 溶液浓度 光学低相干 光谱半高宽度 

分 类 号：TB96[机械工程—光学工程] TH741[一般工业技术—计量学]