药物性皮疹的临床相关因素分析  

作　　者：陈玲玲 陈熔杰 

机构地区：[1]浙江省慈溪市人民医院药剂科,315300 [2]浙江省慈溪市妇幼保健院麻醉科,315300

出　　处：《浙江临床医学》2018年第6期1061-1063,共3页Zhejiang Clinical Medical Journal

摘　　要：目的研究药物性皮疹的发病规律，分析药物、机体和药物性皮疹间的相互关系，探究引起药物性皮疹的临床相关因素。方法收集本院关于药物性皮疹的病例，并统计分析。结果引起药疹的药物依次为抗感染类（25．87％）、抗痛风类（14．83％）、中药制剂（10．76％）、解热镇痛药（8．14％）、抗癫痫药（9．30％）。药疹以多型红斑型、剥脱性皮炎、麻疹型猩红热型药疹及荨麻疹型药疹最为常见。结论药物性皮疹与年龄、致敏药物种类、过敏史存在一定关系，与性别、给药途径、是否合并用药无明显关联，有些药物如卡马西平、别嘌醇与HLA基因存在强烈关联。Objective To study the pathogenesis of drug rash and analyze the relationship between drug, organism and drug rash and explore the clinical relative factors of drug rash. Methods The cases of drug rash were collected and analyzed. Results The main sensitization drugs were anti-infective drugs （25.87%） , anti-gout drugs （14.83%） , traditional Chinese medicine （10.76%） , antipyretic analgesics （8.14%） , and antiepileptic drugs （9.30%） .The rash was most common with multiple types of erythema, stripping dermatitis, measles type scarlet fever, and hives. Conclusion There is a certain relationship between drug rash with age, the type of sensitization drugs and allergies .However, gender, dosing way, whether the drug combination have no obvious correlation with drug rash.Some drugs such as carbamazepine, allopurinol are associated with HLA genes strongly.

关 键 词：药物性皮疹 重型药疹 致敏药物 因素分析 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]