瑞舒伐他汀钙片用于2型糖尿病肾功能保护及调脂作用观察  

作　　者：饶祖华[1] 余颖[1] 江淼[1] 张波庆 李芳 

机构地区：[1]浙江省常山县人民医院,324200

出　　处：《浙江临床医学》2018年第6期1081-1083,共3页Zhejiang Clinical Medical Journal

摘　　要：目的观察瑞舒伐他汀钙片对2型糖尿病患者肾功能的保护作用及调脂作用，分析瑞舒伐他汀对早期糖尿病患者的肾功能保护机制。方法纳入2016年1月至2017年12月接受治疗的140例2型糖尿病伴早期糖尿病肾病患者，采用信封随机法划分为观察组、对照组每组各70例。对照组接受常规降糖、降压及饮食干预；观察组在此基础上联用瑞舒伐他汀钙片，两组疗程均为4周。分别于治疗前、治疗后检测所有患者空腹血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、尿白蛋白／肌酐比值（UACR）、血肌酐（Scr）、超敏C反应蛋白（hs-CRP）及空腹血糖水平。比较两组总体、两组中脂代谢异常者、两组中脂代谢正常者上述指标的差异。结果治疗前，两组总体、脂代谢异常者及脂代谢正常者TC、TG、HDL-C、LDL-C、UACR、Scr、hs-CRP及空腹血糖比较，差异无统计学意义（P〉0．05）。治疗后，两组总体比较，观察纽TC、TG、LDL-C、UACR、Scr、hs-CRP均明显低于对照组；观察组中脂代谢异常者TC、TG、LDL-C、UACR、Scr、hs-CRP均明显低于对照组观察组中脂代谢正常者UACR、Scr、hs-CRP明显低于对照组，上述差异均有统计学意义（P〈0．05）。结论瑞舒伐他汀钙片对2型糖尿病伴早期糖尿病肾病患者的肾功能有一定保护作用，这可能与其调脂及抗炎作用有关。Objective To observe the effect of rosuvastatin calcium tablets on renal function and lipid metabolism in patients with type 2 diabetes, and to analyze the protective mechanism of rosuvastatin on renal function in patients with early diabetic nephropathy. Methods 140 patients with type 2 diabetes and early diabetic nephropathy treated in our hospital from January 2016 to December 2017 were randomly divided into observation group and control group, with 70 cases in each group. The control group received conventional hypoglycemic, antihypertensive and diet intervention, while the observation group were treated with rosuvastatin calcium tablets in addition. Both groups were treated for 4 weeks. The total cholesterol （ TC ） , triglyceride （ TG ） , high density lipoprotein - cholesterol （ HDL-C ） and low density lipoprotein - cholesterol （ LDL-C ） in fasting serum, urinary albumin/creatinine ratio （ UACR ） , serum creatinine （ Scr ） and fasting blood glucosem in patients before and after treatment were observed. The differences of these indexes in total patients, in patients with abnormal lipid metabolism, in patients without abnormal lipid metabolism in 2 groups were analyzed. Results Before treatment, there was no statistically significant differences in TC, TG, HDL-C, LDL-C, UACR, Scr, hs-CRP and fasting blood glucose between total patients in 2 groups, between patients with abnormal lipid metabolism in 2 groups, between patients without abnormal lipid metabolism in 2 groups （P〉0.05） . After treatment, TC, TG, LDL-C, UACR, Scr and hs-CRP in total patients of the observation group were much lower than those of the contorl group, TC, TG, LDL-C, UACR, Scr and hs-CRP in patients with abnormal lipid metabolism of the observation group were much lower than those of the contorl group, UACR, Scr and hs-CRP in patients without abnormal lipid metabolism of the observation group were much lower than those of the contorl group, the differences were statistically significant （ P〈0.05 ） . Conc

关 键 词：2型糖尿病 肾功能 脂代谢 瑞舒伐他汀钙片 

分 类 号：R972.6[医药卫生—药品]