维生素D与呼吸系统感染性疾病  

Vitamin D and the diseases of respiratory infection

作　　者：武莉莉[1] 刘春丽[2] WU Lili;LIU Chunli(Department of Respiratory, Shenzhen Second People＇s Hospital, Shenzhen 518035;Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, China)

机构地区：[1]深圳市第二人民医院呼吸内科,广东深圳518035 [2]广州呼吸疾病研究所,广东广州510120

出　　处：《华夏医学》2018年第2期159-163,共5页Acta Medicinae Sinica

基　　金：深圳市科技创新委员会自由探索项目(JCYJ20160425104021619)

摘　　要：维生素D作为固醇类衍生物,其经典作用为调节血液中钙磷动态平衡及维护骨骼健康。近年来研究显示维生素D与多种呼吸道慢性疾病及自身免疫性疾病相关。维生素D可刺激先天性免疫应答,下调适应性免疫系统。维生素D缺乏可增加呼吸系统感染的发生率,如结核、真菌、病毒感染等,维生素D缺乏的患者更容易合并呼吸道慢性细菌定植。维生素D补充剂被发现可以显著增加无感染的可能性,并在患有频繁性呼吸道感染的患者中可以延长至第一次呼吸道感染的时间。Vitamin D as steroidal derivatives,its classic role is for regulating dynamic balance of calcium and phosphorus in the blood and maintaining health of bones. In recent years,studies have shown that vitamin D is associated with a variety of chronic respiratory disease and autoimmune disease. Vitamin D stimulates the innate immune response and lowers the adaptive immune system. Vitamin D deficiency may increase the incidence of respiratory tract infections（ RTIs）,such as tuberculosis,fungal and virus infection etc. The vitamin D deficient patients are more frequently with respiratory tract chronic bacteria colonization. Vitamin D supplementation was found to significantly increase the probality of staying infection free and prolong the time to the first RTI in patients with frequent RTIs.

关 键 词：25-羟基维生素D 阻塞性睡眠呼吸暂停综合征 慢性阻塞性肺疾病 结核 慢性细菌定植 

分 类 号：R56[医药卫生—呼吸系统]