精蛋白锌胰岛素治疗猫糖尿病并发急性肾衰病例分析  

Administration of protamine zinc insulin in treating diabetes-complicated acute renal failure in a cat

作　　者：翟晓虎[1] 朱庆 周媛丽[1] 狄和双[1] 贺卫华[1] ZHAI Xiaohu;ZHU Qing;ZHOU Yuanli;DI Heshuang;HE Weihua(Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225300, China;Changzhou Zhonglou District Agricultural Service Station, Changzhou 213023, China)

机构地区：[1]江苏农牧科技职业学院,江苏泰州225300 [2]常州市钟楼区北港农业服务站,江苏常州213023

出　　处：《畜牧与兽医》2018年第6期122-124,共3页Animal Husbandry & Veterinary Medicine

基　　金：江苏省高校品牌专业建设工程资助项目(PPZY2015C230);江苏农牧科技职业学院院级课题(NSFPT201730)

摘　　要：为了研究长效胰岛素精蛋白锌胰岛素对猫糖尿病并发急性肾衰病例的治疗效果,采用精蛋白锌胰岛素（PZI）控制血糖,早、晚餐前1 h时按0.5 U/kg皮下注射PZI,每隔2 h检测1次血糖浓度并作血糖曲线,同时按40 mL/kg、15 mL/h静脉输液乳酸林格氏液和生理盐水。结果显示：经过2周治疗,血糖降至8.33 mmol/L,肌酐和尿素氮恢复到正常范围;无氮质血症症状、酮症酸中毒症状已基本消失,尿酮体已降至阴性。结果表明：皮下注射精蛋白锌胰岛素结合输液疗法能够有效控制血糖及纠正急性肾衰,从而达到延长动物生命的目的。This research was to analyze the effect of protamine zinc insulin（ PZI） in treating diabetes-complicated acute renal failure in cat. PZI（ 0. 5 U/kg） was administrated by subcutaneous injection one hour before breakfast and supper. The blood glucose concentration was monitored every two hours to draw a curve of blood glucose. Lactated Ringer＇s solution and physiological saline were given by i. v. infusions at the speed of 15 mL/h and the dose of 40 mL/kg. After treatment for two weeks,the blood glucose concentration was reduced to a manageable level. Creatinine and urea nitrogen were back in abnormal ranges. The clinical symptoms of azotemia and ketoacidosis disappeared. Urine acetone bodies turned negative again in urine. These results suggested that administration of PZI by subcutaneous injection combined with fluid therapy could control blood glucose concentration and improve physical state caused by acute renal failure and achieve the aim of prolonging animal life.

关 键 词：素精蛋白锌胰岛素 糖尿病 急性肾衰 猫 

分 类 号：S856[农业科学—临床兽医学]