快速康复外科治疗对老年胃癌患者术后感染相关并发症及炎性反应的影响  

Effects of rapid rehabilitation surgery on postoperative infection related complications and inflammatory response in senile patients with gastric cancer

作　　者：傅金龙 王先法[1] 汪勇[1] 胡可 黄坚 洪强 FU Jin-long;WANG Xian-fa;WANG Yong;HU Ke;HUANG Jian;HONG Qiang(Sir Run Run Shaw Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China)

机构地区：[1]浙江大学医学院附属邵逸夫医院普外科,浙江杭州310016 [2]浙江省金华市中医医院外二科,浙江金华321000 [3]浙江省金华广福医院胃肠肿瘤外科,浙江金华321000

出　　处：《中华医院感染学杂志》2018年第11期1689-1692,共4页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生一般研究计划基金资助项目(2015KYB219)

摘　　要：目的探讨快速康复外科治疗对胃癌患者术后感染相关并发症及炎性反应的影响。方法选择医院2013年1月-2016年12月手术治疗的老年胃癌患者70例为研究对象,分为试验组和对照组,各35例。试验组进行快速康复外科治疗,对照组采用常规治疗;收集患者临床资料,比较两组患者手术前后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-10及降钙素原(PCT)水平。结果试验组术后排气时间、住院费用、术后住院时间分别为(3.43±0.37)天、(4.12±0.56)万元、(9.89±0.47)天少于对照组(P<0.05);术后试验组患者TNF-α、IL-6、PCT分别为(25.46±2.28)ng/L、(37.67±4.46)ng/L、(2.99±1.42)μg/L低于对照组(P<0.05),IL-10为(36.46±3.12)ng/L水平高于对照组(P<0.05);试验组患者发生并发症12例少于对照组30例(P<0.001)。结论快速康复外科治疗可降低胃癌患者术后排气时间、住院费用、术后住院时间,降低术后炎症反应,具有一定的临床价值。OBJECTIVE To investigate the effects of rapid rehabilitation surgery on postoperative infection related complications and inflammatory response in patients with gastric cancer.METHODS Seventy patients with senile gastric cancer surgically treated in our hospital from Jan.2013 to Dec.2016 were selected as study subjects,and were divided into experimental group（35 cases）and control group（35 cases）.The experimental group was treated with rapid rehabilitation and the control group was treated with routine treatment.The clinical data of the patients were collected.The levels of tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）,interleukin-10（IL-10）,and procalcitonin（PCT）of the two groups were compared.RESULTS The postoperative exhaust time,hospitalization cost and postoperative hospital stay of experimental group were（3.43±0.37）days,（4.12±0.56）×10000 yuan and（9.89±0.47）days,which were less than those of control group（P〈0.05）.The levels of TNF-α,IL-6 and PCT of experimental group were（25.46±2.28）ng/L,（37.67±4.46）ng/L and（2.99±1.42）μg/L,which were lower than those of control group（P〈0.05）.The level of IL-10 of experimental group was（36.46±3.12）ng/L,which was significantly higher than that of control group（P〈0.05）.There were 12 cases of complication in the experimental group,which were significantly less than 30 cases in the control group（P〈0.001）.CONCLUSIONRapid rehabilitation of surgical treatment can reduce postoperative exhaust time,hospitalization costs and postoperative hospital stay in gastric cancer patients,and reduce the postoperative inflammatory response,which has a certain clinical value.

关 键 词：快速康复外科治疗 胃癌 术后感染 炎性反应 并发症 

分 类 号：R619.3[医药卫生—外科学]