双氯芬酸钠-壳聚糖缓释膜的制备及体外释药性能研究  

Preparation and In Vitro Release Property Research of Diclofenac Sodium Chitosan Sustained-Release Membrane

作　　者：杨艾玲 殷义霞[2] 张庆霞 魏君梅 林凤杰 YANG Ai-ling;YIN Yi-xia;ZHANG Qing-xia;WEI Jun-mei;LIN Feng-jie(Biological and Pharmaceutical Engineering Department,Wuhan Huaxia University of Technology,Wuhan 430223, China;State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China)

机构地区：[1]武汉华夏理工学院生物与制药工程学院,湖北武汉430223 [2]武汉理工大学材料复合新技术国家重点实验室,湖北武汉430070

出　　处：《化学试剂》2018年第6期567-570,600,共5页Chemical Reagents

基　　金：国家自然科学基金青年基金项目(51403168);湖北省教育厅科研计划指导性项目(B2014280);武汉华夏理工学院科研项目(13014)

摘　　要：通过均匀试验设计优选双氯芬酸钠-壳聚糖缓释膜的制备工艺,并进行该载药膜体外释放度方法学研究,测定其体外释放度,利用模型方程对累计释放率数据进行拟合,探讨其体外释药机理。结果表明,双氯芬酸钠-壳聚糖缓释膜最优制备工艺为壳聚糖浓度为30 mg/m L、壳聚糖分子量为40万、双氯芬酸钠投药量为0.60 g、乙酸浓度为3%。体外释放度方法学研究可靠,双氯芬酸钠-壳聚糖缓释膜可实现长期缓慢释药,体外释放符合Hixcon-Crowell溶蚀方程。The preparation technology of diclofenac sodium-chitosan sustained-release membrane were selected by uniform test.The in vitro release methodology research were conducted,and in vitro release ratio were measured. The cumulative release ratio data were fitted by release model equations to discuss in vitro release mechanism. The optimum preparation conditions were that chitosan concentration 30 mg/m L,chitosan,molecular weight 400 000,diclofenac quantity 0. 60 g,acetic acid concentration 3%.The methodology research results of in vitro release was reliable.The long and slow release process of diclofenac sodium chitosan sustained-release membrane can be realized and its behavior was matched to Hixcon-Crowell corrosion equation.

关 键 词：双氯芬酸钠 壳聚糖 缓释膜 体外释药 方程拟合 

分 类 号：TQ469[化学工程—制药化工]