抗病毒天然免疫、炎症与癌变机制  

Mechanisms of Antiviral Innate Immunity,Inflammations and Tumorigenesis

作　　者：曹盼 胡浩 罗威伟 李姝 Cao Pan;Hu Hao;Luo Weiwei;Li Shu(College of Life Science, Wuhan University, Wuhan 430072;Office of Scientific Research, Division of Research Program, Wuhan University, Wuhan 430072;Wuhan institute of Virology, Wuhan 430071;Medical Research Institute, Wuhan University, Wuhan 430072)

机构地区：[1]武汉大学生命科学学院,武汉430072 [2]武汉大学科学技术发展研究院,武汉430072 [3]中国科学院武汉病毒所,武汉430071 [4]武汉大学医学研究院,武汉430072

出　　处：《中国基础科学》2018年第1期22-24,29,共4页China Basic Science

基　　金：国家重点研发计划蛋白质与生命过程调控专项项目(2017YFA0505800)

摘　　要：免疫反应是宿主防御病原感染、组织损伤和细胞癌变等危险信号的保护机制,受到精密调控。而失调的免疫反应是诱发急慢性炎症、自身免疫和肿瘤等多类重大疾病的关键因素。本项目以抗病毒天然免疫与炎症反应信号转导调控、适应性免疫细胞调控炎症反应以及组织免疫(炎性)微环境调控炎症反应及癌变的机制等3个相互关联的研究方向为重点,从分子、细胞、动物模型及人类临床样本等多层面上贯通研究,系统阐述病毒诱发的免疫反应的动态调节网络、炎症与癌变的关系等,并以此为基础发展相关疾病的新型免疫干预策略。The innate immune response is an important mechanism that protects the host from pathogenic infections, tissue damages, cell transformations and other dangerous signals. It is precisely regulated in the cells. Uncontrolled immune responses cause severe side effects such as acute and chronic inflammations, autoimmune diseases and cancers. Our researches will mainly focus on three correlative directions including antiviral innate immune responses, inflammation, tissue immune/inflammatory microenvironment-regulated inflammatory responses and inflammation-mediated tumorigenesis. We will systematically illustrate the mechanism of virusestriggered immune responses, inflammation and tumorigenesis, and provide new strategies to treat some relevant diseases.

关 键 词：抗病毒天然免疫应答 炎症反应 炎癌转化 

分 类 号：R392[医药卫生—免疫学]