高分辨率外周定量计算机断层扫描评估骨小梁微结构和骨强度的研究进展  

Review of high-resolution peripheral quantitative computed tomography for the assessment of bone microstructure and strength

作　　者：马剑雄 赵杰[2,3] 何伟伟[2,3] 匡明杰[2,3] 陈恒亭[2,3] 张禄凯 孙磊 崔玉红 马信龙 王颖[2,3] MA Jianxiong;ZHAO Jie;HE Weiwei;KUANG Mingjie;CHEN Hengting;ZHANG Lukai;SUN Lei;CUI Yuhong;MA Xinlong;WANG Ying(School of Mechanical Engineering, Tianjin University, Tianjin 300072, P.R.China;Orthopaedics Institute, Tianjin Hospital, Tianjin 300211, P.R.China;Orthopaedics Institute, Tianfin University Tianjin Hospital, Tianjin 300211, P.R.China)

机构地区：[1]天津大学机械学院,天津300072 [2]天津市天津医院骨科研究所,天津300211 [3]天津大学天津医院骨科研究所,天津300211

出　　处：《生物医学工程学杂志》2018年第3期468-474,共7页Journal of Biomedical Engineering

基　　金：国家重点研发计划项目(2016YFC0105805);国家自然科学基金(11772226;81673994;81571723);中国博士后科学基金面上资助(2017M621087);天津市卫生局科技攻关项目(15KG123;2014KY31);天津市博士后创新项目择优资助项目(TJQYBSH2017017)

摘　　要：骨小梁微结构是决定骨强度及其生理功能的重要因素,而普通X线与计算机断层扫描(CT)检查不能精确反映骨小梁的真实微结构。高分辨率外周定量计算机断层扫描(HR-p QCT)是近年来新兴的一项影像学检测技术,能够定性、定量测量体内骨小梁三维微结构和体积骨矿物质密度,具有极高的精度和相对低剂量的辐射。这种新型成像工具有利于我们更加深入地认识骨小梁微结构,利用HR-p QCT数据进行有限元分析建模计算,能够准确预测骨强度,结合三维重建图像及骨小梁微结构参数还能够评估骨质疏松和骨折风险。在本综述中,我们总结了HR-p QCT的技术流程、数据参数及其临床应用等内容,以期为HR-p QCT的普及和广泛应用提供一定参考。Trabecular microstructure is an important factor in determining bone strength and physiological function. Normal X-ray and computed tomography（CT） cannot accurately reflect the microstructure of trabecular bone.High-resolution peripheral quantitative computed tomography（HR-p QCT） is a new imaging technique in recent years. It can qualitatively and quantitatively measure the three-dimensional microstructure and volume bone mineral density of trabecular bone in vivo. It has high precision and relative low dose of radiation. This new imaging tool is helpful for us to understand the trabecular microstructure more deeply. The finite element analysis of HR-p QCT data can be used to predict the bone strength accurately. We can assess the risk of osteoporosis and fracture with three-dimensional reconstructed images and trabecular microstructure parameters. In this review, we summarize the technical flow, data parameters and clinical application of HR-p QCT in order to provide some reference for the popularization and extensive application of HR-p QCT.

关 键 词：高分辨率外周定量计算机断层扫描 骨小梁微结构 骨密度 骨强度 

分 类 号：R816.8[医药卫生—放射医学]