含石墨烯仿生滑液对ZrO_2陶瓷人工关节材料的润滑作用研究  

Graphene Containing Fluid for the Lubrication of Artifical Joint Material ZrO_2

作　　者：王莹莹[1] 郁惠敏 刘蕾[1] 王晓 梁风光 宋仕永[1] WANG Yingying;YU Huamin;LIU Lei;WANG Xiao;LIANG Fengguang;SONG Shiyong(Institute of Pharmacy, Pharmaceutical College of Henan University, Henan Kaifeng 475004, China;Department of Orthopedics, Huaihe Hospital of Henan University, Henan Kaifeng 475001, China)

机构地区：[1]河南大学药学院药物研究所,河南开封475004 [2]河南大学淮河医院骨科,河南开封475001

出　　处：《摩擦学学报》2018年第3期319-326,共8页Tribology

基　　金：国家自然科学基金项目(51375142);河南省科技发展计划项目(172102310285)资助~~

摘　　要：为解决植入人工关节润滑不充分而引起的过早失效问题,文中制备了一种基于石墨烯的仿生关节滑液.借助氧化石墨烯拥有较好的润滑性能和透明质酸(HA)良好的生物相容性制备了水分散性较好的氧化石墨烯透明质酸(HA-GO)纳米复合材料作为仿生关节润滑液添加剂.通过核磁共振氢谱、红外光谱、热重分析、原子力扫描显微镜等对HA-GO进行了表征,并考察了其在不同分散介质中的分散性和稳定性.将HA-GO加入到HA基础溶液里配制成HA+HA-GO人工关节润滑液,系统考察了石墨烯基仿生关节液对ZrO_2陶瓷人工关节材料的减摩抗磨作用,结果显示HA+HA-GO仿生关节液具有明显的减摩抗磨性能且具有良好的生物相容性.In this study, a graphene oxide（GO） containing biomimic fluid was prepared for the lubrication of artificial joint, considering the poor lubrication condition and premature failure of artificial joint. A nanoscale hybrid material（GO-HA） was used as an additive with good lubricating effect of GO and good biocompatibility of hyaluronic acid（HA）, which was characterized by -1H-NMR, FTIR, TGA, AFM. The modified GO with HA was found very stable in various medium compared with naked GO. A serial of fluids were formulated by adding different amount of GO-HA into HA solutions. The performance of the lubrication fluids were examined on a tribo-meter using a ZrO2 ball-on-plate model. The results show that the HA-GO containing fluid had obvious friction reducing and antiwear properties compared with HA solution. MTT experiment also confirmed the good biocompatibility of the fluid.

关 键 词：氧化石墨烯 透明质酸 摩擦学性能 生物相容性 

分 类 号：TH117.1[机械工程—机械设计及理论]