2011至2016年梅毒患者抗体实验室检测结果分析  

Analysis of laboratory test results of syphilis antibody from 2011 to 2016

作　　者：夏欢[1] 邱梅花[1] 巫翠云[1] Xia Huan;Qiu Meihua;Wu Cuiyun(Department of Clinical Laboratory, Haikou People＇s Hospital, Haikou 570102, China)

机构地区：[1]海口市人民医院检验科,570102

出　　处：《中华传染病杂志》2018年第3期164-167,共4页Chinese Journal of Infectious Diseases

摘　　要：目的 通过检测入院患者梅毒抗体,了解梅毒感染状况.方法 回顾性分析2011年至2016年海口市人民医院199498例就诊患者梅毒抗体检测结果.采用ELISA法检测梅毒密螺旋体抗体,甲苯胺红不加热血清反应素试验（tolulized red unheated serum test,TRUST）检测非密螺旋体抗体.对ELISA法检测阳性者,采用梅毒螺旋体明胶颗粒凝集试验（treponema pallidum particle agglutination assay,T PPA）复查确认.统计学分析采用卡方检验.结果 梅毒密螺旋体抗体确认阳性7616例,阳性率为3.82％.2011年至2016年分别检测23188、32010、35079、35734、35406和38081例,梅毒密螺旋体抗体确认阳性者分别为952、1261、1597、1376、1229和1201例,阳性率分别为4.11％ 、3.94％ 、4.55％ 、3.85％ 、3.47％ 和3.15％,差异有统计学意义（χ^2=108.167,P〈0.05）.梅毒密螺旋体抗体阳性者男4899例,阳性率为4.85％;女2717例,阳性率为2.76％,差异有统计学意义（χ^2=593.443,P〈0.05）.年龄〉80岁者梅毒密螺旋体抗体确认阳性率为6.09％,年龄〉60岁者总阳性率为5.03％.TRUST阳性共计3413例,阳性率为1.71％.2011年至2016年TRUST阳性者分别为179、390、585、768、816和675例,阳性率分别为0.77％ 、1.22％ 、1.67％ 、2.15％ 、2.3％ 和1.77％,差异有统计学意义（χ^2=763.779,P〈0.05）.男性TRUST阳性2022例,阳性率为2.01％,女性TRUST阳性1391例,阳性率为1.41％,差异有统计学意义（χ^2=102.887,P〈0.05）.2011年至2016年,～9岁、～19岁年龄段TRUST阳性率变化差异均无统计学意义（χ^2值分别为1.198和11.018,均P〉0.05）;而～29岁、～39岁、～49岁、～59岁、～69岁、～79岁、≥80岁年龄段TRUST阳性率变化差异均有统计学意义（χ2值分别为20.100、38.387、89.360、75.874、87.743、71.035和30.593,均P〈0.05）.结论 2011年至2016年海口市人民医院梅毒阳性率呈现先增加后下降的趋势,性别、年龄差异有统计学意义,老年阳�Objective To analyze the results of syphilis serology test results among hospitalized patients ,and to investigate the prevalence of syphilis .Methods T he results of syphilis antibody test of 199498 patients of Haikou People′s Hospital from 2011 to 2016 were retrospectively analyzed . All samples were screened by Treponema pallidum （TP） antibody using enzyme linked immunosorbent assay （ELISA） .Syphilis toluidine red unheated serum reagin test （TRUST ） was used to test nontreponemal antibody .The TP-ELISA positive samples were confirmed by Treponema pallidum particle agglutination test （TPPA） .Chi-square test was used for statistical analysis .Results A total of 7616 cases were positive of anti-TP ,with positive rate of 3 .82% .From 2011 to 2016 ,the annual cases tested were 23188 ,32010 ,35079 ,35734 ,35406 and 38081 ,respectively .The annual positive rates of anti-TP w ere 4 .11% （952/23188 ） ,3 .94% （1261/32010 ） ,4 .55% （1597/35079 ） ,3 .85% （1376/35734 ） , 3 .47% （1229/35406） ,and 3 .15% （1201/38081） ,respectively ,and the difference was statistical significant （χ^2 =108 .167 ,P〈0 .05） .Anti-TP positive rate in male patients was 4 .85% （4899 cases） , and 2 .76% （2717 cases） in female ,and the difference was statistically significant （ χ^2 =593 .443 , P〈0 .05） .The positive rate of TP antibody in the elderly over 80 years old was 6 .09% ,and 5 .03% in patients older than 60 years old .In all samples ,TRUST was positive in 3413 cases （1 .71% ） .From 2011 to 2016 , the annual positive cases were 179 , 390 , 585 , 768 , 816 and 675 , respectively , with coresponding rates of 0 .77% ,1 .22% ,1 .67% ,2 .15% ,2 .3% and 1 .77% ,respectively .The difference was statistically significant （χ^2 = 763 .779 , P〈 0 .05） .TRUST was positive in 2022 （2 .01% ） male patients and 1391 （1 .41% ） female patients ,and the positive rates were significantly different （χ^2 =102 .887 ,P〈0 .05） .From 2011 to 2016 ,the annual TRUST positivities amo

关 键 词：梅毒 抗体 梅毒血清诊断 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R446.6[医药卫生—临床医学]