氧化应激在脊髓损伤中的研究进展  

Research advances on oxidative stress in spinal cord injury

作　　者：张焱 郝剑 李波[1] 孙超[1] 段会全[1] 赵晨曦 郭星 李芳菲 姚雪[1] 冯世庆[1] Zhang Yan;Hao Jian;Li Bo;Sun Chao;Duan Huiquan;Zhao Chenxi;Guo Xing;Li Fangfei;Yao Xue;Feng Shiqing(Department of Orthopedics, Tianjin Medical University General .Hospital, Tianjin 300052, Chin;Department of Gynaecology , Tianjin Medical University Gen- eral Hospital, Tianfin 300052, China;Department of Orthopedics, Nankai Hospital, Tianjin 300100, China)

机构地区：[1]天津医科大学总医院骨科,300052 [2]天津医科大学总医院妇产科,300052 [3]天津市南开医院骨科,300100

出　　处：《中华实验外科杂志》2018年第6期1184-1189,共6页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金重点项目（81330042）;国家自然科学基金国际合作与交流项目（81620108018）;国家科技部中俄合作专项项目（2014DFR31210）;天津市科委重点项目-中澳合作项目（13RCGFSYl9000、14ZCZDSY00044）

摘　　要：脊髓损伤（SCI）是受到直接或间接暴力损伤后导致的一种神经功能障碍的疾病，为脊柱骨折的严重并发症，按损伤机制可分为原发性损伤和继发性损伤，其中氧化应激与SCI继发性损伤的发生发展有着密切的关系。我们通过对SCI中氧化应激作用的研究，进一步阐明SCI继发性损伤的发病机制，并对近年来针对抗氧化治疗出现的抗氧化剂进行分析，为SCI的治疗提供新的方向。Spinal cord injury （SCI） is a neurological disorder disease caused by direct or indirect violence, which is a serious complication of spinal fractures. It can be divided into primary injury and secondary injury by injury mechanism. There is a close relationship between oxidative stress and secondary injury. In this article, the pathogene- sis of secondary injury was further elucidated by the research of oxidative stress in SCI, and the anti - oxidants on anti - oxidative therapy appeared in recent years were analyzed to provide a new direction for SCI treatment.

关 键 词：脊髓损伤 继发性损伤 氧化应激 氧化应激标志物 脊髓损伤相关抗氧化剂 

分 类 号：R651.2[医药卫生—外科学]