儿童呼吸道感染博卡病毒流行病学特征分析  

Epidemiological features of human bocavirus in children with respiratory tract infection

作　　者：谭嘉红 季伟[1] 张新星[1] 顾文婧[1] 陈正荣[1] 严永东[1] 王美娟[1] 邵雪君[1] 黄莉[1] TAN Jia-hong;JI Wei;ZHANG Xin- xing(Department of Respiratory Diseases, Children＇ s Hospital of Sooehow University, Suzhou 2]5003, Chin)

机构地区：[1]苏州大学附属儿童医院呼吸科,江苏苏州215003

出　　处：《中国实用儿科杂志》2018年第6期445-448,共4页Chinese Journal of Practical Pediatrics

基　　金：苏州市民生科技关键技术应用研究(SS201765);苏州市应用基础研究(医疗卫生)项目(SYS201558;SYSD2016101);江苏省卫生计生委面上科研课题(H201622)

摘　　要：目的分析儿童呼吸道感染博卡病毒(human bocavirus,HBo V)流行病学特征,为临床合理诊治提供参考依据。方法收集2009年1月至2016年12月在苏州大学附属儿童医院呼吸科住院治疗的16 913例呼吸道感染患儿的痰标本和临床资料,采用实时荧光定量PCR法检测HBo V,分析HBo V检出情况。结果 16 913例患儿中,HBo V阳性检出率为5.16%(873/16913例)。男性患儿HBo V阳性检出率为5.42%(573/10566例),女性患儿为4.73%(300/6347例),男性患儿HBo V检出率高于女性患儿(χ2=3.928,P=0.047)。<1岁、~3岁、~7岁以及≥7岁患儿的HBo V检出率分别为4.03%(325/7963例)、8.75%(401/4584例)、3.99%(134/3357例)、1.29%(13/1009例),各年龄组HBo V检出率差异有统计学意义(χ2=182.075,P<0.01)。春夏秋冬四季HBo V阳性检出率分别为3.36%(146/4341例)、6.92%(295/4261例)、6.88%(287/4172例)、3.50%(145/4139例),夏秋季患儿HBo V阳性检出率明显高于冬春季(χ2=93.801,P<0.01)。结论苏州大学附属儿童医院2009年1月至2016年12月呼吸道感染患儿HBo V检出率为5.16%,幼儿HBo V检出率高,男性患儿高于女性。夏秋季为HBo V感染的高发季节。Objective To analyze the epidemiological characteristics of human bocavirus （HBoV） infection in children with respiratory tract diseases, and to provide scientific basis for clinical diagnosis and treatment. Methods Sputum specimens and clinical informations of 16 913 cases of hospitalized children with respiratory tract diseases from January 2009 to December 2016 in Children＇s Hospital of Sooehow University were collected. HBoV DNA was detected by fluo- rescence quantitative polymerase chain reaction at real time to analyze the detections. Results The HBoV detection rate was 5.16%（873/16 913 cases） in 16 913 children. The HBoV detection rate of boys was 5.42%（573/10 566 cases）, which was significantly higher than that of girls [ 4.73% （300/6 347 eases）, X2 = 3.928, P = 0.047 ]. The HBoV detection rate of children at the age of less than 1 year old, -3 years old, -7 years old and older than 7 years old were 4.03%, 8.75%, 3.99% and 1.29%, respectively, the difference of which had statistical significance （X2= 182.075, P 〈 0.01 ）. The HBoV detection rate in spring, summer, autumn and winter were 3.36% （146/4341 cases） , 6.92% （295/4261 cases） , 6.88% （287/4172 cases） and 3.50% （145/4139 cases） , respectively. The HBoV detection rate in summer and autumn was significantly higher than that in spring and winter （X2= 93.801, P 〈 0.01 ）. Conclusions The HBoV detection rate in children with respiratory tract diseases is 5.16% in Suzhou area from Jan. 2009 to Dec. 2016. The highest HBoV detee-tion rate is high in infant, especially in boys. Epidemical seasons of HBoV infection in Suzhou are summer and au- tumn.

关 键 词：博卡病毒 呼吸道感染 流行病学 儿童 

分 类 号：R72[医药卫生—儿科]