新城疫病毒包膜糖蛋白的结构与功能  

The Structure and Function of Enveloped Glycoproteins of Newcastle Disease Virus

作　　者：刘亚轻 王志玉 LIU Yaqing;WANG Zhiyu(Department of Virology, School of Public Health, Shandong University, Jinan 250012, China)

机构地区：[1]山东大学公共卫生学院病毒学研究室

出　　处：《病毒学报》2018年第4期617-624,共8页Chinese Journal of Virology

基　　金：国家自然科学基金(项目号:81672011),题目:副粘病毒HN蛋白颈部与自身头部、F蛋白的相互作用及机制~~

摘　　要：新城疫是一种禽类传染病,可对养禽业带来严重的经济损失。其病原新城疫病毒具有包膜,基因组是单股、负链、不分节段的RNA,具有溶瘤活性,编码NP、P、M、F、HN和L六种结构蛋白,其中位于病毒包膜上的融合蛋白（F）和血凝素-神经氨酸酶（HN）两种糖蛋白对NDV的入侵及毒力有着重要的作用。本文首先总结了两种包膜糖蛋白结构与功能的基本情况,在此基础上,整合了近年来国内外的研究,发现了一些矛盾点,并且将HN蛋白的其他功能进行概述,为NDV包膜糖蛋白的研究提供了新的视角。Newcastle disease is an avian infectious disease that can cause serious economic losses to the poultry industry.The pathogen,Newcastle disease virus（NDV）,has an envelope,with oncolytic activity.Its genome is a non-segmented single-stranded,negative-sense RNA,encoding six structural proteins,including NP,P,M,F,HN and L.Fusion protein（F）and hemagglutinin-neuraminidase（HN）on the viral envelope have significant roles in the invasion and virulence of NDV.Here,we summarize the basic studies on the structure and function of these two types of enveloped glycoprotein.Furthermore,we investigate the studies conducted in China and overseas in recent years,find some contradictory points,and summarize the other functions of HN protein.Our summary provides new perspectives on the research into the enveloped glycoproteins of NDV.

关 键 词：新城疫病毒(NDV) 包膜糖蛋白 F蛋白 HN蛋白 结构与功能 

分 类 号：S852.65[农业科学—基础兽医学]