复凝聚法制备非诺贝特微囊的工艺研究  

Preparation of Fenofibrate Microcapsule by Complex Coacervation

作　　者：郭君 刘佳佳[1] Guo Jun;Liu Jiajia(College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China)

机构地区：[1]中南大学化学化工学院,湖南长沙410083

出　　处：《广东化工》2018年第11期6-7,共2页Guangdong Chemical Industry

摘　　要：应用明胶-壳聚糖复凝聚体系对非诺贝特微囊的制备工艺进行了研究。通过对囊材浓度、复凝聚pH值、复凝聚温度、固化温度等参数进行考察,得到非诺贝特微囊的制备参数:囊材浓度为20%明胶液(明胶∶壳聚糖=10∶1),复凝聚pH=6.0,复凝聚温度为55℃,固化温度为45℃。The preparation of fenofibrate microcapsules was studied by gelatin-chitosan complex coacervation system. The research results indicate that Preparation parameters of fenofibrate microcapsules is： 20 % Gelatin liquid, Complex Coacervation pH=6, Coacervation temperature is 55 ℃, curing temperature is 45℃.

关 键 词：复凝聚 非诺贝特 

分 类 号：TQ460.6[化学工程—制药化工]