局部枸橼酸抗凝血液灌流在妊娠合并高脂血症性胰腺炎中的应用  

Application of sodium citrate anticoagulant for hemoperfusion in hypertriglyceridemia-induced acute pancreatitis in pregnancy

作　　者：高元妹[1] 黄东健[1] 廖广园[1] 李静[1] 甘朝晖 徐仲[1] 陈敦金[2] Gao Yuanmei;Huang Dong]ian;Liao Guangyuan;Li Jing;Gan Zhaohui;Xu Zhong;Chen Dunjin(Department of Intensive Care Unit, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China;Department of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou ,510150, Chin)

机构地区：[1]广州医科大学附属第三医院重症医学科,510150 [2]广州医科大学附属第三医院产科,510150

出　　处：《中华产科急救电子杂志》2018年第1期48-51,共4页Chinese Journal of Obstetric Emergency（Electronic Edition）

基　　金：广东省自然科学基金资助(立项编号:2017A030313857)

摘　　要：目的探讨局部枸橼酸抗凝血液灌流治疗妊娠合并高脂血症性胰腺炎的效果。方法回顾性分析19例妊娠合并高脂血症性胰腺炎患者的临床资料,对比局部枸橼酸抗凝的血液灌流治疗前、后患者的临床表现和实验室指标。结果 19例患者行局部枸橼酸抗凝的血液灌流后,ACPAHEⅡ评分由(14.8±4.7)分将至(6.3±1.3)分(t=5.167,P<0.001),甘油三酯由(30.44±7.37)mmol/L降至(4.5±1.2)mmol/L(t=5.167,P<0.001),血淀粉酶由(1028.76±293.27)U/L降至(105.3±65.1)U/L(t=2.861,P=0.011)。结论局部枸橼酸抗凝的血液灌流改善临床症状和患者预后。Objective To explore the curative effect of sodium citrate anticoagulant for hemoperfusion on hypertriglyceridemia-induced acute pancreatitis in pregnancy. Methods A retrospective study was conducted in 19 pregnant patients with hypertriglyceridemia-induced acute pancreatitis. The clinical manifestation and laboratory index of the patients before and after hemoperfusion with sodium citrate anticoagulant were compared. Results After hemoperfusion with sodium citrate anticoagulant, the ACPAHEⅡ scores of patients reduced from（ 14. 8 ± 4. 7） scores to（ 6. 3 ± 1. 3） scores,t = 5. 167,triglyceride from（ 30. 44 ± 7. 37） mmol/L to（ 4. 5 ± 1. 2） mmol/L,t = 5. 167,amylase from（ 1028. 76 ±293. 27） U/L to（ 105. 3 ± 65. 1） U/L,t = 2. 861,all P 〈0. 01. Conclusion The hemoperfusion with sodium citrate anticoagulant can improve clinical symptom and prognosis of pregnant patients with hypertriglyceridemia-induced acute pancreatitis.

关 键 词：枸橘属 灌流 血液 妊娠并发症 高脂血症 胰腺炎 

分 类 号：R714.255[医药卫生—妇产科学] R714.256[医药卫生—临床医学]