2型糖尿病合并腔隙性脑梗死患者血清高迁移率族蛋白B1水平及其相关因素分析  

Levels of serum high mobility group protein B1 and its related factors in patients with type 2 diabetes mellitus complicated with lacunar cerebral infarct

作　　者：巫小燕 叶程程 杨宏 阮园[2] WU Xiao-yan;YE Cheng-cheng;YANG Hang(Department of Endocrinology, Wenzhou Hospital of Traditional Chinese Medicine Union Hospital, Wenzhou, Zhejiang 325000, Chin)

机构地区：[1]温州市中西医结合医院内分泌科,浙江温州325000 [2]浙江医院内分泌科,浙江杭州310003

出　　处：《中华全科医学》2018年第8期1275-1278,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生一般研究计划项目(2014KYB008)

摘　　要：目的探讨2型糖尿病合并腔隙性脑梗死患者血清高迁移率族蛋白B1水平及其相关因素。方法 2型糖尿病患者280例作为糖尿病组,2型糖尿病合并腔隙性脑梗死患者280例作为糖尿病+脑梗死组,健康体检者280例作为对照组。测定患者血清高迁移率族蛋白B1水平和空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果糖尿病组和糖尿病+脑梗死组血清高迁移率族蛋白B1水平高于对照组(P<0.05),且糖尿病组+脑梗死组高于糖尿病组(P<0.05)。糖尿病组和糖尿病+脑梗死组FBG、Hb A1c、FINS、HOMA-IR、TG、TC、LDL-C高于对照组且糖尿病+脑梗死组高于糖尿病组,糖尿病组和糖尿病+脑梗死组HDL-C低于对照组,且糖尿病组+脑梗死组低于糖尿病组(P<0.05)。糖尿病+脑梗死患者血清高迁移率族蛋白B1水平与FBG、Hb A1c、FINS、HOMA-IR、TG、TC、LDL-C水平呈正相关(P<0.05),与HDL-C呈负相关(P<0.05)。FINS、HOMA-IR、TG、TC、LDL-C、HDL-C是血清高迁移率族蛋白B1的影响因素(P<0.05)。结论 2型糖尿病合并腔隙性脑梗死患者血清高迁移率族蛋白B1水平升高,其水平受FINS、HOMA-IR、TG、TC、LDL-C、HDL-C影响。Objective To explore the serum high mobility group protein B1 and its related factors in patients with type 2 diabetes mellitus complicated with lacunar cerebral infarction. Methods Total 280 patients with type 2 diabetes mellitus complicated with lacunar infarction were selected as diabetes mellitus ＋ cerebral infarction group, 280 cases of type 2 di- abetes mellitus were selected as the diabetic group, and 280 cases of healthy subjects were selected as control group. The levels of serum high mobility group protein B1 and fasting blood glucose （FBG）, glycated hemoglobin （HbAlc）, fasting insulin （ FINS）, Insulin resistance index （ HOMA-IR）, Triglycerides （ TG）, total cholesterol （ TC）, low density lipo- protein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） were tested. Results The level of serum high mobility group protein B1 in diabetes group and diabetes ＋ cerebral infarction group was higher than that in the control group （P 〈 0.05 ）, and the blood in diabetic group ＋ cerebral infarction group was higher than that in the diabetes group （P 〈0.05）. FBG, HbAlc, FINS, HOMA-IR, TG, TC and LDL-C in diabetes group and diabetes mellitus ＋ cerebral infarction group were higher than those in the control group, and their levels in the diabetes mellitus ＋ cerebral infarction group was higher than that in the diabetic group; HDL-C level in the diabetes group and diabetes mellitus ＋ cerebral infarction group were lower than that in the control group, and HDL-C in the diabetic group and cerebral infarc- tion group were lower than that in the diabetic group （P 〈0.05）. The level of serum high mobility group protein B1 in patients with diabetes and cerebral infarction was positively correlated with FBG, HbAlc, FINS, HOMA-IR, TG, TC and LDL-C levels （P 〈 0.05 ）, and negatively correlated with HDL-C （P 〈 0.05）. FINS, HOMA-IR, TG, TC, LDL-C, HDL-C were the factors affecting the serum high mobility group protein B1 （P 〈 0. 05 ）. Conc

关 键 词：2型糖尿病 腔隙性脑梗死 高迁移率族蛋白B1 

分 类 号：R587.1[医药卫生—内分泌] R743.3[医药卫生—内科学]