中西医结合方案对非ST段抬高型急性冠状动脉综合征保守治疗患者的临床研究  

The Effect of Therapy Combining TCM with Western Medicine on NSTEACS

作　　者：李艳青[1] 谢荃[2] 张晓云[2] na）

机构地区：[1]成都中医药大学,四川成都610072 [2]成都中医药大学附属医院,四川成都610072

出　　处：《中国中医急症》2018年第6期941-943,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局课题(zylc20160914)

摘　　要：目的观察中西医结合方案对非ST段抬高型急性冠状动脉综合征(NSTEACS)保守治疗患者的疗效并探讨其机制。方法 62例患者随机分为两组。对照组采用西医常规药物治疗,观察组在对照组基础上加用膈下逐瘀汤、瓜蒌薤白半夏汤合方+人参山楂饮,疗程10 d,观察治疗前后心绞痛分级、发作次数、持续时间与血液流变学指标。结果治疗后观察组心绞痛分级、发作次数、持续时间低于对照组(均P<0.05)。观察组总有效率为75.00%,高于对照组的63.33%(P<0.05)。治疗前两组全血黏度、血浆纤维蛋白原水平比较,差别均不大(均P>0.05)。治疗后两组全血黏度、血浆纤维蛋白原水平与治疗前比较,均降低(均P<0.05),但观察组与对照组比较差别不大(均P>0.05)。治疗期间,观察组4例出现可能与治疗药物有关的恶心、胃脘不适,未作处理,继续服药后症状消失;对照组3例出现可能与治疗药物有关的胃脘不适、牙龈出血,未作处理,继续服药后症状消失。经治疗前后血常规、小便常规、肝肾功能检查结果对比,未发现可能与治疗药物有关的指标异常加重的情况。观察组不良事件发生率1.25%与对照组不良事件发生率1.00%比较差别不大(P>0.05)。结论中西医结合方案对NSTEACS有治疗作用,较单纯西医治疗有优势。Objective： To observe the effect of therapy combining TCM and Western medicine on NSTEACS. Methods： 62 patients were randomly divided into two groups. The control group was treated with conventional medicine in Western Medicine,while on the basis of the control group,the observation group was treated with Gexia Zhuyu Decoction, Gualou Xiebai Banxia Decoction plus Ginseng Hawthorn Drink. The treatment course lased for 10 days. The changes of the CCS class,frequency of angina pectoris attack,duration of attack and hemorheological indexes were observed. Results： After treatment,the angina pectoris grade, seizure frequency and duration of the observation group were lower than those of the control group （P〈 0.05）. The effective rate of the observation group was 75.00%, higher than that of the control group （63.33%） （P 〈 0.05）. Before treatment, there was no significant difference in blood viscosity and plasma fibrinogen level between the two groups（P〉 0.05）. After treatment, the total blood viscosity and plasma fibrinogen level of the two groups were lower than those before treatment （P〈 0.05）,but there was little difference between the observation group and the control group （P〉 0.05）. During treatment,4 patients in the observation group had nausea and epigastric discomfort which might be related to treatment. Without dealing,symptoms disappeared after continuing to take medicine. In the control group,there were 3 cases of epigastric discomfort and gingival bleeding which might be related to treatment. Without treatment, the symptoms disappeared after continuing to take the medicine. The comparison of blood rou- tine test, urine routine test and liver and kidney function test results before and after treatment showed no signs of abnormal treatment. The incidence of adverse events in the observation group was 1.25% ,which was not significantly different from that in the control group（P〉 0.05）. The incidence of adverse events in the control group was 1.00%. Conclusion： Th

关 键 词：非ST段抬高型急性冠状动脉综合征 膈下逐瘀汤 人参山楂饮 疗效观察 

分 类 号：R541.4[医药卫生—心血管疾病]