中药熏蒸联合鹿瓜多肽治疗老年急性膝骨关节炎患者的临床研究  

Influence of Chinese Herbal Fumigation Combined with Cervus and Cucumis Polypeptide on Elderly Patients with Acute Knee Osteoarthritis

作　　者：管义红[1] 周瑞明 Guan Yihong;Zhou Ruiming(Taihe Hospital of Hubei Medical College ,Hubei ,Shiyan 442000, Chin)

机构地区：[1]湖北医药学院附属太和医院,湖北十堰442000 [2]湖北医药学院附属人民医院,湖北十堰442000

出　　处：《中国中医急症》2018年第6期982-985,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：湖北省自然科学基金项目(2015CFC035)

摘　　要：目的观察中药熏蒸联合鹿瓜多肽治疗老年急性膝骨关节炎(KOA)患者临床疗效及对血液流变性、血管内皮生长因子(VEGF)和膝关节功能的影响并探讨其作用机制。方法患者134例按照随机数字表法分为两组,均给予健康教育、饮食、运动等基础干预,在此基础上对照组给予鹿瓜多肽治疗,观察组在对照组基础上联合中药熏蒸治疗。观察两组中医证候积分、症状缓解时间、膝关节功能、临床疗效、血液流变学指标,同时检测VEGF水平。结果治疗后两组中医证候积分均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);观察组疼痛缓解时间、晨僵缓解时间、肿胀缓解时间均短于对照组(均P<0.05);治疗后两组疼痛、功能、活动度、稳定性评分均高于治疗前(均P<0.05),且观察组均高于对照组(均P<0.05);观察组总有效率为94.03%,高于对照组的80.60%(P<0.05);治疗后两组全血黏度高切值、纤维蛋白原、全血黏度低切值、血浆黏度均低于治疗前(均P<0.05),且观察组均低于对照组(均P<0.05);治疗后两组VEGF水平均低于治疗前(均P<0.05),且观察组低于对照组(P<0.05)。结论中药熏蒸联合鹿瓜多肽可有效改善老年急性KOA患者血液流变学指标和膝关节功能,提高临床疗效。Objective： To explore the influence of Chinese herbal fumigation combined with cervus and cucumis polypeptide on clinical efficacy,hemorheology,vascular endothelial growth factor（VEGF） and function of knee joint of elderly patients with acute knee osteoarthritis（KOA）. Methods： 134 cases of elderly patients with KOA were divided into the observation group and the control group according to random number table method.Both two groups were given basic intervention such as health education,diet and exercise,on the basis of which,the control group were given cervus and cucumis polypeptide treatment,and the observation group were combined with Chinese herbal fumigation on the basis of the control group. The control group were given routine nursing intervention,and the observation group were given full featured rehabilitation nursing of traditional Chinese medicine intervention on the basis of the control group. TCM syndrome scores,symptom relief time,knee function,clinical efficacy and hemorheological indexes were observed,and VEGF level was detected in the two groups. Results： After treatment,TCM symptom scores were significantly lower than those before treatment in the two groups（P〈0.05）,and those in the observation group were significantly lower than those in the control group（P〈0.05）.Pain relief time,remission time and relieve swelling time of morning stiffness of the observation group was significantly lower than that of the control group（P〈0.05）. After treatment,the scores of pain,function,activity and stability were significantly higher than those before treatment in the two groups（P〈0.05）,and those in the observation group were significantly higher than those in the control group（P〈0.05）. Total efficiency of the observation group was 94.03%,significantly higher than that of the control group（80.60%）（P〈0.05）. After treatment,whole blood viscosity at high shear value of fibrinogen,whole blood viscosity at low shear rate and plasma viscosity were significantly l

关 键 词：急性膝骨关节炎 中药熏蒸 鹿瓜多肽 临床疗效 血液流变性 

分 类 号：R684.3[医药卫生—骨科学]