心理社会干预对肺癌患者生活质量影响的Meta分析  

Effect of psychosocial intervention on quality of life in lung cancer survivors: a meta-analysis

作　　者：何红叶 宋永霞[1] 张甜[1] 虞苗 葛晓玲 洪静芳[1] HE Hong-ye;SONG Yong-xia;ZHANG Tian;YU Miao;GE Xiao-ling;HONG Jing-fang(School of Nursing, Anhui Medical University, Hefei 230601, China)

机构地区：[1]安徽医科大学护理学院,安徽合肥230601

出　　处：《现代预防医学》2018年第12期2117-2123,共7页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(81573017);安徽省高校自然科学研究重点项目(KJ2015A083)

摘　　要：目的系统评价心理社会干预对肺癌患者生活质量的影响。方法计算机检索多个中英文数据库,收集关于心理社会干预对肺癌患者生活质量影响的临床随机对照试验,采用Rev Man5.3.0和Stata12.0软件进行数据分析。结果共纳入11项临床随机对照研究。心理社会干预组在干预结束后即刻[SMD=0.33,95%CI(0.16,0.51),P=0.0001]和3个月以内[SMD=0.30,95%CI(0.01,0.59),P=0.04]的总体生活质量评分优于对照组,而在3个月以后,2组无统计学差异(P>0.05)。在功能方面,心理社会干预在提高患者的躯体功能[MD=0.30,95%CI(0.16,0.43),P<0.0001]上有显著作用;而在情绪、认知、角色和社会功能方面,2组无统计学差异(P>0.05)。结论采用心理社会干预,有利于肺癌患者在干预后短期内(≤3个月)生活质量的改善,尤其是在躯体功能方面,而心理社会干预在3个月以后的效果尚不能确定,有待临床开展大样本、设计严谨的临床随机对照研究进一步证实。Objective To evaluate the effect of psychosocial intervention on quality of life（QOL） in lung cancer survivors using meta-analysis. Methods Randomized controlled trials（RCTs） which mentioned the effect of psychosocial intervention on the quality of life in lung cancer survivors were systematically reviewed using multiple electronic databases. Results 11 RCTs were included. The overall QOL score of the intervention group was higher than the control group with statistically significant differences in the immediate effect and within three months effect（ P〈0.05）. The significant differences beyond three months had not been observed between the two groups（P〉0.05）. As for the functional scale of QOL, psychosocial intervention could significantly improve physical function（P〈0.05）. However, the significant differences in emotional, cognitive, role and social function had not been observed between the two groups（P〉0.05）. Conclusion Psychosocial intervention could effectively improve QOL of patients with lung cancer（within three months）, especially in aspects of physical function. The effect of psychosocial intervention on QOL beyond three months is still uncertain. Researches with large sample sizes and more rigorous randomized controlled trials are needed to confirm its long-term effectiveness.

关 键 词：肺癌 心理社会干预 生活质量 META分析 

分 类 号：R181.32[医药卫生—流行病学]