Ti6Al4V表面生物功能纯Mg薄膜制备及性能研究  

Preparation and Properties of Biological Functional Magnesium Coating on Ti6Al4V Substrate

作　　者：于晓明[1] 谭丽丽[1] 刘宗元[1] 杨柯[1] 朱忠林 李扬德 YU Xiaoming;TAN Lili;LIU Zongyuan;YANG Ke;LI Yangde(Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;Jiangsu OKANI Medical Technology Co., Ltd., Suzhou 215123, China;Dong Guan EONTC Co., Ltd., Dongguan 523808, China)

机构地区：[1]中国科学院金属研究所,沈阳110016 [2]江苏奥康尼医疗科技发展有限公司,苏州215123 [3]东莞宜安科技股份有限公司,东莞523808

出　　处：《金属学报》2018年第6期943-949,共7页Acta Metallurgica Sinica

基　　金：国家自然科学基金项目Nos.51631009;81500897和81400528;国家重点研发计划项目No.2016YFC1101804~~

摘　　要：利用多弧离子镀技术在Ti6Al4V表面沉积纯Mg薄膜,研究了工作气压对纯Mg薄膜表面质量及性能的影响,研究了纯Mg薄膜的体外降解等性能、抗菌性及生物安全性能。结果表明:多弧离子镀方法可将纯Mg薄膜制备于钛合金表面,薄膜颗粒均匀致密,未见明显缺陷。体外浸泡实验结果表明:由于Ti6Al4V与Mg发生电偶腐蚀而使Mg薄膜迅速降解,1周时间内薄膜基本降解完毕。抗菌实验结果表明:纯Mg薄膜样品对金黄色葡萄球菌具有强烈的杀灭作用,表现出良好的抗细菌感染功能。细胞毒性实验结果表明:纯Mg薄膜可促进骨髓间充质干细胞(r BMSCs)的增殖。Currently, metallic biomaterials used in orthopedics are normally bioinert which is hard to integrate with the bone tissue inducing aseptic loosening and easy to get infection, which is the main reason of implantation failure. Mg base metals are considered to be a new generation of revolutionary metallic biomaterials due to its similar density and mechanical properties with natural bone, good biocompatibility, degradability in the body as well as the biological functional ability to promote new bone tissue formation. In addition, the degradation of Mg may increase the local p H which can inhibit the growth of bacteria. In this work, pure Mg coating was deposited on Ti6 Al4 V substrate by arc ion plating. The effects of different working pressures on the surface quality and properties of Mg coating were investigated. The degradation, antibacterial and biosafety properties were studyied. The results showed that the pure Mg coating can be deposited on the surface of Ti6 Al4 V substrate and the coating was uniform and smooth. The immersion test in vitro showed that the degradation was very fast because of galvanic corrosion, and the whole process was finished in about one week. The results of antimicrobial experiments showed that the Mg coating can kill staphylococcus aureus and showed good antibacterial function. The results of cytotoxicity test showed that Mg coating promoted rabbit bone marrow mesenchymal stem cells（r BMSCs）growth and proliferation.

关 键 词：钛合金 纯Mg薄膜 生物性能 

分 类 号：TB741[一般工业技术—材料科学与工程]