注射用磷酸肌酸钠对非体外循环下冠状动脉旁路移植术患者动脉血氧分压、心肌酶及心律失常的影响  

Effects of creatine phosphate sodium on arterial oxygen partial pressure,cardiac enzymes and arrhythmias in CHD patients receiving on-pump coronary artery bypass grafting surgery

作　　者：王圣[1] 黄乾海 程兆云[1] 周胜凯[1] WANG Sheng;HUANG Qian-hai;CHENG Zhao-yun;et al.(Department of Cardiovascular Surgery, Henan Province People＇s Hospital, Zhengzhou 450003, Chin)

机构地区：[1]河南省人民医院心血管外科

出　　处：《中国心血管病研究》2018年第6期562-565,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的：探讨注射用磷酸肌酸钠对冠状动脉旁路移植术（CABG）患者动脉血氧分压、心肌酶及心律失常的影响。方法：70例本院ASA分级Ⅱ～Ⅲ级，CABG预术患者，随机分成对照组和实验组，每组35例。麻醉完毕后，给予对照组患者常规药物及液体应用,而实验组则在对照组基础上给予磷酸肌酸钠1g静脉滴注。术毕时血气分析检测动脉血氧分压；术后24h检测心肌酶谱；术后24h记录Ⅱ导联心电图心律失常发生情况。结果： 相比对照组，实验组术毕动脉血氧分压提高显著（p〈0.05）；两组心肌酶含量术后均升高，实验组上升较对照组明显减少（p〈0.05）；实验组心律失常的发生率8.5%，明显低于对照组37.1%（p〈0.05）。结论：磷酸肌酸钠能提高冠心病手术患者动脉血氧分压，改善心肌酶含量，降低心律失常发生率。Objective：To study the effects of creatine phosphate sodium on arterial oxygen partial pressure, cardiac enzymes and arrhythmias in CHD patients receiving on-pump coronary artery bypass grafting surgery.Methods：70 CHD patients,ASAⅡ～Ⅲ, undergoing coronary artery bypass grafting, were randomly divided into two groups, control group and study group.The patients of control group were treated by conventional drugs,and the patients of study group were treated by 1g Phosphocrentine. Observe arterial oxygen partial pressure.Test cardiac enzyme levels after operation 24h.II-lead ECG was recorded to monitor arrhythmia after operation 24h. Results： Compared with control group,there was an increase in arterial oxygen partial pressure of study group.The amplitudes of cardiac enzyme levels increase in study group were lower than that in control group. The incidence of arrhythmia in study group was much lower than in control group.Conclusions： Creatine phosphate sodium can increase arterial oxygen partial pressure; decrease cardiac enzyme levels; reduce arrhythmia in CHD patients.

关 键 词：磷酸肌酸钠 冠状动脉疾病 动脉血氧分压 心肌酶 心律失常 

分 类 号：R654.2[医药卫生—外科学]