Density gradient ultracentrifugation for colloidal nanostructures separation and investigation  

作　　者：Pengsong Li Anuj Kumar Jun Ma Yun Kuang Liang Luo Xiaoming Sun 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,College of Energy,Beijing Advanced Innovation Center for Soft Matter Science and Engineering,Beijing University of Chemical Technology

出　　处：《Science Bulletin》2018年第10期645-662,共18页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC);the National Key Research and Development Project of China(2016YFF0204402);the Program for Changjiang Scholars and Innovative Research Team in the University(IRT1205);the Fundamental Research Funds for the Central Universities,the Long-Term Subsidy Mechanism from the Ministry of Finance and the Ministry of Education of PRC

摘　　要：In this article,we review the advancement in nanoseparation and concomitant purification of nanoparticles(NPs) by using density gradient ultracentrifugation technique(DGUC) and demonstrated by taking several typical examples.Study emphasizes the conceptual advances in classification,mechanism of DGUC and synthesis-structure-property relationships of NPs to provide the significant clue for the further synthesis optimization.Separation,concentration,and purification of NPs by DGUC can be achieved at the same time by introducing the water/oil interfaces into the separation chamber.We can develop an efficient method ‘‘lab in a tube" by introducing a reaction zone or an assembly zone in the gradient to find the surface reaction and assembly mechanism of NPs since the reaction time can be precisely controlled and the chemical environment change can be extremely fast.Finally,to achieve the best separation parameters for the colloidal systems,we gave the mathematical descriptions and computational optimized models as a new direction for making practicable and predictable DGUC separation method.Thus,it can be helpful for an efficient separation as well as for the synthesis optimization,assembly and surface reactions as a potential cornerstone for the future development in the nanotechnology and this review can be served as a plethora of advanced notes on the DGUC separation method.In this article,we review the advancement in nanoseparation and concomitant purification of nanoparticles（NPs） by using density gradient ultracentrifugation technique（DGUC） and demonstrated by taking several typical examples.Study emphasizes the conceptual advances in classification,mechanism of DGUC and synthesis-structure-property relationships of NPs to provide the significant clue for the further synthesis optimization.Separation,concentration,and purification of NPs by DGUC can be achieved at the same time by introducing the water/oil interfaces into the separation chamber.We can develop an efficient method “lab in a tube” by introducing a reaction zone or an assembly zone in the gradient to find the surface reaction and assembly mechanism of NPs since the reaction time can be precisely controlled and the chemical environment change can be extremely fast.Finally,to achieve the best separation parameters for the colloidal systems,we gave the mathematical descriptions and computational optimized models as a new direction for making practicable and predictable DGUC separation method.Thus,it can be helpful for an efficient separation as well as for the synthesis optimization,assembly and surface reactions as a potential cornerstone for the future development in the nanotechnology and this review can be served as a plethora of advanced notes on the DGUC separation method.

关 键 词：Density gradient ultracentrifugation Isopycnic separation Rate zonal separation Colloidal nanostructure Nanoseparation 

分 类 号：TB383.1[一般工业技术—材料科学与工程]