抑郁障碍情绪对普外科老年患者术后炎症因子、应激反应及康复进程的影响  

Effects of Depressive Disorder on Postoperative Inflammatory Factors,Stress Responses and Rehabilitation Progress of Elderly Patients in the Department of General Surgery

作　　者：许琪[1] 荣秀华[1] XU Qi;RONG Xiuhua(The outpatient department, The second people＇s Hospital of Chengdu , Chengdu 610017,China)

机构地区：[1]四川省成都市第二人民医院门诊部

出　　处：《中国健康心理学杂志》2018年第7期1010-1013,共4页China Journal of Health Psychology

摘　　要：目的：探究抑郁障碍情绪对普外科老年患者术后炎症因子、应激反应及康复进程的影响。方法：选取2015年3月-2017年4月于我院普外科门诊行手术治疗的136例老年患者为研究对象,以SDS评分≥40分为抑郁障碍情绪评价标准,将44例抑郁障碍情绪患者分为观察组,92例无抑郁障碍情绪患者分为对照组,比较两组术后炎症因子水平[白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）]、应激反应指标[白细胞（WBC）、C反应蛋白（CRP）、皮质醇]及康复进程指标（VAS评分、肠鸣音恢复时间、排便时间、下床时间和住院时间）。结果：观察组术后1d和术后5dIL-6、IL-8、TNF-α等炎症因子水平均显著高于对照组（t=4.961,2.231,2.619,2.231,4.774,4.774;P〈0.05）;观察组术后1d和术后5d WBC、CRP、皮质醇等应激反应指标均显著高于对照组（t=1.999,3.351,2.029,2.533,1.992,2.014;P〈0.05）;观察组术后5dVAS评分显著高于对照组,肠鸣音恢复时间、排便时间、下床时间以及住院时间均显著长于对照组（t=2.178,6.951,8.272,2.946,9.748;P〈0.05）;观察组术后生活质量总分显著低于对照组（t=-5.003,P〈0.05）。结论：抑郁障碍情绪可导致普外科老年患者术后炎症因子水平显著增加,加重机体应激反应,影响患者术后康复进程,应引起临床重视。Objective：To explore the effects of depressive disorder on postoperative inflammatory factors,stress responses and rehabilitation process in elderly patients in the department of general surgery.Methods：A total of 136 elderly patients treated in the department of general surgery of our hospital from March 2015 to April 2017 were selected for the study and divided into the observation group（n=44,patients with depressive disorder）and the control group（n=92,patients without depressive disorder）according to the evaluation criteria of depressive disorder with SDS score≥40 points.The levels of inflammatory factors[interleukin-6（IL-6）,interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）],stress response indexes[white blood cell（WBC）,C-reactive protein（CRP）,cortisol]and rehabilitation progress indexes[VAS score,bowel sounds recovery time,defecation time,bedtime and hospital stay]were compared between the two groups.Conclusion：After treatment,the levels of IL-6,IL-8 and TNF-αin the observation group were significantly higher than those in the control group（t=4.961,2.231,2.619,2.231,4.774,4.774;P〈0.05）.The stress response indexes of WBC,CRP and cortisol were significantly higher in the observation group than those in the control group（t=1.999,3.351,2.029,2.533,1.992,2.014;P〈0.05）.After treatment,the VAS score of the observation group was significantly higher than that of the control group,and the bowel sounds recovery time,defecation time,bed time and hospital stay were significantly longer in the observation group than those in the control group（t=2.178,6.951,8.272,2.946,9.748;P〈0.05）.The quality of life scores in the observation group were significantly lower than those in the control group（t=-5.003,P〈0.05）.Conclusion：Depressive disorder can significantly increase the postoperative inflammatory factors levels and the body stress responses,and affect the postoperative rehabilitation process in elderly patients in the department of general surgery.Therefore

关 键 词：抑郁障碍 普外科老年患者 炎症因子 应激反应 康复进程 

分 类 号：R395.9[哲学宗教—心理学]