炎症相关因素在非瓣膜病性心房颤动病情发展中的作用  

Clinical study on inflammatory related factors in patients with non-valvular atrial fibrillation

作　　者：曾国良[1] 黄杰雄[1] 邓斌[1] 罗伶俐[1] Zeng Guoliang;Huang Jiexiong;Deng Bin;Luo Lingli(Department of Cardiovascular Medicine, Zhaoqing First People＇ s Hospital, Zhaoqing 526000, Chin)

机构地区：[1]广东省肇庆市第一人民医院心血管内科,526000

出　　处：《中国实用医刊》2018年第11期17-19,23,共4页Chinese Journal of Practical Medicine

基　　金：肇庆市科技计划项目（201504030816）

摘　　要：目的观察非瓣膜病性心房颤动患者炎症相关因素与其疾病发生、发展的相关性。方法采用回顾性分析法，选取150例非瓣膜病性心房颤动患者作为房颤组，其中慢性心房颤动（NPAF）99例，阵发性房颤（PAF）患者51例；99例NPAF患者中持续性心房颤动者58例，永久性心房颤动者41例。另选取同期100例窦性心律患者作为对照组。所有患者均接受血清C-反应蛋白（CRP）及高密度脂蛋白胆固醇（HDL-C）检查；并在房颤组患者中抽取100例患者接受阿托伐他汀治疗12周，观察患者治疗前后血清CRP及HDL-C水平变化情况。结果房颤组及对照组患者一般资料比较差异未见统计学意义（P〉0.05）；房颤组患者血清CRP水平高于对照组，HDL-C水平低于对照组，差异有统计学意义（P〈0.05）；持续性房颤组血清CRP水平高于阵发性房颤组，HDL-C水平低于阵发性房颤组，差异有统计学意义（P〈0.05）；100例房颤组患者接受阿托伐他汀治疗后12周其血清CRP水平较治疗前降低，HDL-C水平较治疗前升高，差异有统计学意义（P〈0.05）。结论血清CRP水平升高及HDL-C水平降低可能是导致房颤发生的关键诱因之一，CRP、HDL-C可能对心房颤动的发生、维持有一定的预测作用，在心房颤动患者中应用他汀类药物治疗，可能有助于抑制炎症反应、减少房颤发生、维持，对改善其预后有着积极意义。ObjectiveTo observe the correlation of inflammatory related factors with development of disease in patients with non-valvular atrial fibrillation （NVAF）.MethodsAll the data were retrospectively analyzed. A total of 150 NVAF patients were selected as atrial fibrillation group, including 99 cases of non-paroxysmal atrial fibrillation （NPAF） and 51 cases of paroxysmal atrial fibrillation （PAF）; 99 cases of NPAF included 58 cases of persistent atrial fibrillation and 41 cases of permanent atrial fibrillation. And 100 patients with sinus rhythm were selected as control group. All the patients underwent serum C-reactive protein （CRP） and high density lipoprotein cholesterol （HDL-C） examination. And 100 patients selected from atrial fibrillation group were treated with atorvastatin for 12 weeks. The changes of serum CRP and HDL-C of patients were observed before and after treatment.ResultsThere was no statistically significant difference in the general information between atrial fibrillation group and control group （P〉0.05）; the level of serum CRP in atrial fibrillation group was higher than that in control group, but the level of HDL-C was lower than control group （P〈0.05）; the level of serum CRP in persistent atrial fibrillation group was higher than that in paroxysmal atrial fibrillation group, but the level of HDL-C was lower than paroxysmal atrial fibrillation group （P〈0.05）; after 100 patients in atrial fibrillation group were treated with atorvastatin for 12 weeks, the serum CRP levels decreased compared with those before treatment, the HDL-C levels increased compared with those before treatment （P〈0.05）.ConclusionsThe increased CRP and decreased HDL-C levels are key risk drives of causing atrial fibrillation, probably. CRP and HDL-C possibly can predict the occurrence and maintenance of atrial fibrillation. The application of statins in patients with atrial fibrillation can inhibit inflammatory response, reduce the occurrence and maintenance of atrial fibrillation, whi

关 键 词：心房颤动 炎症 C-反应蛋白 高密度脂蛋白胆固醇 

分 类 号：R541.75[医药卫生—心血管疾病]