不同种类胰岛素治疗胃癌合并糖尿病的效果分析  

Effects of different types of insulin on gastric cancer with diabetes mellitus

作　　者：文博 宋展[2] Wen Bo;Song Zhan Graduate(School of Xinxiang Medical University, Xinxiang 453000, Chin;Department of Gen- eral Surgery, Nanyang Central Hospital, Affiliated Hospital of Zhengzhou University, Nanyang 473009, Chin)

机构地区：[1]新乡医学院研究生学院,河南新乡453000 [2]郑州大学附属医院南阳市中心医院普通外科,河南南阳473009

出　　处：《中国实用医刊》2018年第11期114-116,共3页Chinese Journal of Practical Medicine

摘　　要：目的比较不同种类胰岛素对胃癌合并糖尿病患者血糖控制效果的差异，初步筛选胃癌合并糖尿病的适宜胰岛素。方法随机选取132例胃癌合并糖尿病患者，根据所用胰岛素种类分为甘精胰岛素组（使用优乐灵治疗）47例、门冬胰岛素组（使用诺和锐50治疗）42例、短效胰岛素组（使用优泌林R治疗）43例，比较分析三组治疗前后空腹血糖（FBG）水平、糖化血红蛋白（HbA1c）变化情况，比较三组不良反应发生率。结果治疗后3 d，三组FBG、HbA1c水平均明显低于治疗前（P〈0.05），甘精胰岛素组FBG、HbA1c水平明显低于门冬胰岛素组、短效胰岛素组，门冬胰岛素组FBG、HbA1c水平明显低于短效胰岛素组，甘精胰岛素组、门冬胰岛素组血糖达标时间、不良反应发生率明显低于短效胰岛素组，差异有统计学意义（P〈0.05）；甘精胰岛素组血糖达标时间、不良反应发生率低于短效胰岛素组，但差异未见统计学意义（P〉0.05）。结论与门冬胰岛素、短效胰岛素治疗比较，胃癌合并糖尿病患者使用甘精胰岛素治疗不仅血糖控制效果更理想，而且使用安全性更好。Objective To compare the glycemic contM effects of different kinds of insulin on patients with gastric cancer and diabetes mellitus. Methods One hundred and thirty-two patients with gastric cancer and diabetes mellitys were selected randomly, and were divided into insulin glargine group （47 cases, treated with Youleling）, insulin aspart group （42 cases, treated with NovoMix 50） and short acting insulin group （43 cases, treated with C. Lin R）. Levels of fasting blood glucose （FBG）, glycosy- lated hemoglobin （HbA1 c） and the incidence of adverse reactions were compared among the three groups before and after treatment. Results At three days after treatment, the FBG and HbAlc of three groups were significantly lower than those before treatment （ P 〈 O. 05 ） , the FBG and HbAI c of insulin glargine group were significantly lower than those of insulin aspart group and short acting insulin group; the FBG and HbA 1 c of insulin aspart group were significantly lower than those of short acting insulin group; the time of blood glucose reaching standared and the incidence of adverse reactions in insulin glargine group and insulin aspart group were significantly lower than those in short acting insulin group, the difference was statistically significant （ P 〈 0.05 ） ; the time of blood glucose reaching stadard, the incidence of ad- verse reaction in insulin glargine group were lightly lower than those in short acting insulin group, but the difference was not statistically significant （P 〉 0. 05 ）. Conclusions Compared with insulin aspart and short acting insulin, insulin glargine is not only effective in controlling blood glucose but also safe for pa- tients with gastric cancer and diabetes mellitus.

关 键 词：胃癌 糖尿病 甘精胰岛素 门冬胰岛素 短效胰岛素 

分 类 号：R587.1[医药卫生—内分泌]