血清CA125联合超声卵黄囊检测预测早期先兆流产预后临床意义  

Clinical Study of Serum CA125 Combined with Yolk Sac in Predicting the Prognosis of Early Threatened Abortion

作　　者：梁岚[1] 廖明珠[1] 黄敏葵[1] LIANG Lan;LIAO Mingzhu;HUANG Minkui(Department of Gynecology, People＇s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China)

机构地区：[1]广西壮族自治区人民医院妇科,南宁530021

出　　处：《航空航天医学杂志》2018年第4期393-396,共4页Journal of Aerospace medicine

基　　金：广西壮族自治区卫生厅科研项目(编号Z2013359)

摘　　要：目的探究血清CA125联合超声检测卵黄囊的综合评估体系预测早期先兆流产预后的临床意义。方法收集2013年1月-2014年6月诊治早期妊娠的120例孕妇,其中包括40例早期正常妊娠孕妇,80例早期妊娠先兆流产孕妇;跟踪随访至孕28周,依据妊娠结局分为先兆流产保胎成功组54例(良好组)、先兆流产保胎失败组26例(不良组)、早期妊娠正常组40例(对照组);于治疗前及治疗后1、2、3周检测CA125及B超监测卵黄囊大小,比较两个指标单独及联合评估早期妊娠先兆流产结局的准确度、特异度及灵敏度。结果血清CA125>52.20 ng/mL,预测先兆流产结局的灵敏度、特异度及准确率分别为88.9%(48/54)、84.6%(22/26)、87.5%(70/80);卵黄囊预测先兆流产结局的灵敏度、特异度及准确率分别92.6%(50/54)、46.2%(12/26)、77.5%(62/80)。以同时满足超声检查卵黄囊不可见或卵黄囊直径超过正常上线,血清CA125>52.2 U/mL的综合指标为依据,预测先兆流产结局的灵敏度、特异度及准确率分别为90.3%(48/54)、94.2%(24/26)、89%(71/80)。结论综合血清CA125及超声卵黄囊量两组指标对先兆流产结局的特异度及准确度单一及联合检测指标数据的比较,说明血清CA125联合超声卵黄囊检测预测早期先兆流产结局具有重要意义。Objective To investigate the predictive value of serum CA125 combined with ultrasound in the assessment of the prognosis of threatened abortion. Methods From January 2013 to June 2014 in our hospital obstetrics and gynecology clinic diagnosed as early pregnancy and 120 cases of pregnant women,including pregnant women,80 cases of threatened abortion in early pregnancy,40 cases of early normal pregnancy; followed up to 28 weeks of pregnancy,according to pregnancy outcome in early pregnancy is divided into normal group（ control group）,40 cases of threatened miscarriage abortion group 54 cases（ Group）,26 cases of threatened abortion Baotai failure group（ experimental group）; before and after treatment in 1,2 and 3 weeks CA125 and ultrasound monitoring of yolk sac size,three sensitivity and early pregnancy outcome of threatened abortion alone and in combination with the evaluation index specificity and accuracy. Results The results of the sensitivity,the yolk sac of predicting the outcome of threatened abortion. The specificity and accuracy were 92. 6%（50/54）,46. 2%（12/26）,77. 5%（62/80）;serum CA125 52. 20 ng/mL; predicting the outcome of threatened abortion,the sensitivity,specificity and accuracy were 88. 9%（ 48/54）,84. 6%（22/26）,87. 5%（70/80）; to meet the diameter of yolk sac ultrasound invisible or yolk sac exceeds the normal line,and at the same time to meet the comprehensive index of serum CA125 〉52. 2 U/mL basis predicting the outcome of threatened abortion of the sensitivity, specificity and accuracy were 90. 3%（ 48/54）,94. 2%（ 24/26）,89%（71/80）. Conclusions the combination of yolk sac and CA125 in three groups can improve the specificity and accuracy of threatened abortion. This study provides a theoretical and practical basis for clinical evaluation of Early Threatened Abortion.

关 键 词：先兆流产 CA125 卵黄囊 预后评估 

分 类 号：R714.21[医药卫生—妇产科学]