黄腐酸及人参皂苷Rg1对蛋白磷酸酯酶2A影响的初步研究  

A Preliminary Study on the Effect of Protein Phosphatase 2A Affected by Fulvic Acid and Ginsenoside Rg1

作　　者：张彩凤[1,2] 刘志帆 宋珍 袁雯[1,2] 李林 邓晨华[1,2] 刘翠仙 Zhang Caifeng;Liu Zhifan;Song Zhen;Yuan Wen;Li Lin;Deng Chenhua;Liu Cuixian(Taiyuan Normal University Department of Chemistry, Taiyuan, 030619;Humic Acid Engineering and Technology Research Center of Shanxi Province, Taiyuan, 030619;Taiyuan Normal University Department of Physics, Taiyuan, 030619)

机构地区：[1]太原师范学院化学系,太原030619 [2]山西省腐植酸工程技术研究中心,太原030619 [3]太原师范学院物理系,太原030619

出　　处：《腐植酸》2018年第3期47-55,63,共10页Humic Acid

基　　金："1331山西省腐植酸产业协同创新中心";国家自然科学基金(项目编号51174275);山西省自然科学基金(项目编号201601D102010)

摘　　要：要:利用分子模拟平台Discovery Studio 4.5研究分析黄腐酸和三七中人参皂苷Rg1分别对蛋白磷酸酯酶2A(Protein phosphatase2A,PP2A)的影响。结果表明,人参皂苷Rg1通过促进PP2A的活性以减少tau蛋白的过度磷酸化,从而防治阿尔茨海默病(Alzheimer disease,AD)。采用CDOCKER对接技术对黄腐酸和人参皂苷Rg1分别与PP2A结合研究表明,黄腐酸也可能与PP2A发生作用,减少tau蛋白的过度磷酸化。与人参皂苷Rg1和PP2A形成的复合物对接结果表明,黄腐酸可能促进人参皂苷Rg1与PP2A的结合,从而增强PP2A的药理活性。The effects of fulvic acid and ginsenoside Rg1 in notoginsengon respectively acting on protein phosphatase 2（PP2A）were studied by the molecular simulation platform Discovery Studio 4.5.The results showed that ginsenoside Rg1 in notoginseng could promote the activity of PP2A,so as to reduce the hyperphosphorylation of tau protein,in order to prevent Alzheimer disease.Using CDOCKER technology to fulvic acid and ginsenoside Rg1 respectively with PP2A,the combination concluded fulvic acid with PP2A reduce the hyperphosphorylation of tau protein.Ginsenoside Rg1 and PP2A complexes was formed by the docking results analysis.The results of docking with ginsenoside Rg1 and PP2A indicated that fulvic acid could promote the binding of ginsenoside Rg1 to PP2A,thus enhancing the pharmacological activity of PP2A.

关 键 词：黄腐酸 三七 人参皂苷RG1 蛋白磷酸酯酶2A(PP2A) 

分 类 号：TQ314.1[化学工程—高聚物工业] S567.236[农业科学—中草药栽培]