卵巢储备功能下降中医证型分布研究  

Research on Traditional Chinese Medicine Syndrome Type Distribution in Decreasing Ovarian Store

作　　者：赵巍[1] 郑锦[1] 徐莲薇[1] 刘敛[1] 董莉[2] 胡国华[3] ZHAO Wei;ZHENG Jin;XU Lianwei;LIU Lian;DONG Li;HU Guohua(Gynecology Department of Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Gynecology Department of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai 200437,China;Gynecology Department of Shanghai Municipal Hospital of Traditional Chinese Medicine ,Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China)

机构地区：[1]上海中医药大学附属龙华医院妇科,上海200032 [2]上海中医药大学附属岳阳中西医结合医院妇科,上海200437 [3]上海中医药大学附属市中医医院妇科,上海200071

出　　处：《山东中医杂志》2018年第6期475-478,509,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划(编号:ZY3-JSFC-1-1010);国家自然科学基金资助项目(编号:81273794)

摘　　要：目的：通过文献分析卵巢储备功能下降（DOS）患者常见中医证型,临床调查统计分析DOS患者的中医证候,经专家评审统计结果,最终得出其中医证型分布情况,为临床辨证分型和规范化治疗提供依据。方法：分析近10年文献中DOS的中医证型分布和常见证候。根据文献和临床实际设计临床DOS中医证候调查表;对130例患者进行临床调查,采用SPSS 16.0主成分分析和聚类分析方法分析归类证型分布情况,根据聚类分析结果再通过15名同领域专家评审筛选出最优结果。结果：130例卵巢储备功能下降患者所得证型分布为肝郁血瘀证30.77%,脾肾两虚证23.08%,肾虚血瘀证37.69%,肝肾阴虚证8.46%。结论：卵巢储备功能下降患者中以肾虚血瘀为主要证型,肝郁血瘀型次之。Objective：Through literature review and clinical survey to analyze the common traditional Chinese medicine（TCM） syndrome types in patients with decreasing ovarian store（DOS）. After experts gave the evaluation,the TCM syndrome type distribution was determined,which could provide a basis for syndrome differ- entiation and treatment standardization of DOS. Methods：TCM syndrome type distribution and the common symptoms of DOS in the literature of the last 10 years were analyzed. According to literatures and clinical practice,a clinical DOS TCM symptoms questionnaire was designed. Total 130 DOS patients were investigated. The principal component analysis and cluster analysis from SPSS 16.0 were performed to analyze and determine the syndrome type distribution. Fifteen experts did peer review and chose the best results. Result：In the 130 DOS patients,the syndrome type distribution was as follows：liver depression and blood stasis accounting for 30.77%,deficiency of spleen and kidneys 23.08%,kidney deficiency and blood stasis 37.69%,yin deficiency of liver and kidneys 8.46%. Conclusion：In patients with DOS,kidney deficiency and blood stasis is the predominant syndrome type,followed by liver depression and blood stasis.

关 键 词：卵巢储备功能下降 中医证型 聚类分析 主成分分析 规范化 

分 类 号：R241.3[医药卫生—中医诊断学]