雷公藤多苷联合甲氨蝶呤治疗类风湿性关节炎短期疗效研究  

Short-term efficacy of tripterygium ployglycosides combined with methotrexate on rheumatoid arthritis

作　　者：张红[1] 薛中柱[1] ZHANG Hong;XUE Zhongzhu(Nanyang Central Hospital, Nanyang 473400, Henan Province, Chin)

机构地区：[1]南阳市中心医院,河南南阳473400

出　　处：《吉林中医药》2018年第6期660-663,共4页Jilin Journal of Chinese Medicine

基　　金：河南省教育科学规划课题(2013-JKGHB-0098)

摘　　要：目的探讨雷公藤多苷联合甲氨蝶呤治疗类风湿性关节炎短期疗效及对患者外周血IL-1、I L-10和TNF-α水平的影响。方法选取我院2015年1月-2016年12月收治的类风湿性关节炎患者72例,根据患者入院治疗药物的不同,将72例患者分为对照组及观察组,各36例。对照组患者采用单纯甲氨蝶呤进行治疗,甲氨蝶呤口服10 mg/次,1次/w。观察组患者采用雷公藤多苷联合甲氨蝶呤进行治疗,甲氨蝶呤口服10 mg/次,1次/w,雷公藤多苷口服10 mg/次,每周1次,2组均连续治疗3个月。观察并比较2组患者的短期临床疗效、治疗前后外周血IL-1、IL-10和TNF-α水平变化及不良反应发生情况。结果观察组患者临床疗效总有效率明显优于对照组(94.44%vs 77.77%),差异有统计学意义(P<0.05);观察组治疗后IL-1水平为(424.21±25.63)pg/mL,明显低于治疗前和同期对照组水平[(452.36±30.23)pg/mL,(442.38±28.69)pg/mL](P<0.05);观察组治疗后IL-10水平为(2.52±0.57)pg/mL,明显高于治疗前和同期对照组水平[(2.06±0.86)pg/mL,(2.09±0.79)pg/mL](P<0.05);观察组治疗后TNF-α为(17.66±5.64)ng/mL,明显低于治疗前和同期对照组[(37.63±8.12)ng/mL,(22.36±7.63)ng/mL](P<0.05);2组患者均未出现严重不良反应。结论雷公藤多苷联合甲氨蝶呤治疗类风湿性关节炎患者短期疗效佳,可有效改善患者外周血IL-1、IL-10和TNF-α水平。Objective To investigate the short-term efficacy of tripterygium glycosides combined with methotrexate on rheumatoid arthritis and its effects on peripheral blood levels of IL-1, IL-10 and TNF-α. Methods 72 cases with rheumatoid arthritis in our hospital from January 2015 to December 2016 were selected and according to the diff erent treatment were divided into control group and observation group with 36 cases in each group. The control group were treated with methotrexate alone（Oral, 10 mg/time, 1 time/w） and the observation group treated with Tripterygium Glycosides（Oral, 10 mg/time, 1 time/w） combined with methotrexate. The two groups were treated continuously for 3 months. The short-term clinical efficacy of the two groups and the changes of IL-1, IL-10 and TNF-α levels in peripheral blood before and after treatment were observed and compared. Results The total curative rate of observation group were significantly higher than that in the control group（94.44% vs 77.77%） with statistically significant difference（P〈00.05）. The IL-1 level in observation group after treatment was（424.21±25.63） pg/ml, which were significantly lower than that before treatment and that in the control group at the same period [（452.36±30.23） pg/mL,（442.38±28.69） pg/mL]（P〈0.05）. The IL-10 level in the observation group after treatment was（2.52±0.57） pg/mL, which was significantly higher than that before treatment and that in the control group at the same period [（2.06±0.86） pg/mL,（2.09±0.79） pg/mL]（P〈00.05）. The TNF-α level in the observation group after treatment was（17.66±5.64） ng/mL, which were significantly lower than that before treatment and in the control group at the same period [（37.63±8.12） ng/mL,（22.36±7.63） ng/mL]（P〈00.05）. There were no serious adverse reaction in two groups. Conclusion Tripterygium glycosides combined with methotrexate in the treatment of patients with rheumatoid arthritis has good short-term curative effect, and can effec

关 键 词：雷公藤多苷 甲氨蝶呤 类风湿性关节炎 

分 类 号：R259.9[医药卫生—中西医结合]