补肾纳气汤对哮喘缓解期患儿炎症因子和肺功能的影响  

Influence of tonifying kidney and activating qi decoction on inflammatory factors and lung function in children with asthma at remission stage

作　　者：刘莉萍 王艳丽 LIU Liping;WANG Yanli(Department of Pediatrics, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830000, Chin)

机构地区：[1]新疆医科大学附属中医医院儿科,乌鲁木齐830000

出　　处：《吉林中医药》2018年第6期666-669,共4页Jilin Journal of Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目(201521235)

摘　　要：目的探讨分析补肾纳气汤对哮喘缓解期患儿炎症因子和肺功能的影响。方法选取2016年1月-2017年6月来我院就诊的哮喘缓解期患儿120例,根据随机数字表法将所有患儿分为观察组和对照组,各60例。对照组患儿接受糖皮质激素吸入治疗,在对照组治疗的基础上,观察组患儿联合服用补肾纳气汤进行治疗。治疗3个月后,对比分析2组患儿的炎症因子水平和肺功能。结果治疗前,2组患儿的IgE、IL-4和IFN-γ水平与对照组相比,差异无统计学意义(P>0.05)。治疗后,观察组患儿的IgE和IL-4明显低于对照组患儿,IFN-γ水平明显高于对照组患儿(P<0.05)。治疗后,观察组的IgE、IL-4和IFN-γ水平与治疗前相比,差异有统计学意义(P<0.001)。对照组患儿治疗前后,IgE、IL-4和IFN-γ水平比较,差异无统计学意义(P>0.05)。治疗前,2组患儿PEF和FEV1水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿的PEF和FEV1水平明显高于对照组(P<0.05)。治疗后,观察组患儿的PEF和FEV1水平与治疗前相比,差异有统计学意义(P<0.05);治疗后,对照组患儿的PEF和FEV1水平与治疗前相比,差异无统计学意义(P>0.05)。结论补肾纳气汤能够有效改善哮喘缓解期患儿的肺功能,降低气道炎症因子水平。Objective To investigate the influence of tonifying kidney and activating qi decoction on inflammatory factors and lung function in children with asthma at remission stage. Methods Selected 120 children with asthma remission were in our hospital from January 2016 to June 2017, all children were randomly divided into observation group and control group, 60 cases in each group. The control group received glucocorticoid inhalation treatment, on the basis of the control group, the observation group were treated with tonifying kidney and activating qi decoction for treatment. After 3 months, the levels of inflammatory factors and lung function in the two groups were compared and analyzed. Results Before treatment, the levels of IgE, IL-4 and IFN-γ in the two groups were not statistically significant（P〉0.05）. After treatment, the IgE and IL-4 in the observation group were significantly lower than those in the control group, and the level of IFN-γ was significantly higher than that of the control group（P〉0.05）. After treatment, the levels of IgE, IL-4 and IFN-γ in the observation group were statistically significant compared with those before treatment（P〈0.001）. There were no statistically significant diff erences in the levels of IgE, IL-4 and IFN-γ between patients in the control group before and after treatment（P〈0.05）. Before treatment, the PEF and FEV1 levels of the two groups were not statistically significant（P〈0.05）. After treatment, the levels of PEF and FEV1 in the observation group were significantly higher than those in the control group（P〈0.05）. After treatment, the observation group compared with PEF and FEV1 levels before treatment, the diff erence was statistically significant（P〈0.05）; after treatment, compared with the control group of patients with PEF and FEV1 levels before treatment, the diff erence was not statistically significant（P〉0.05）. Conclusion tonifying kidney and activating qi decoction can eff ectively improve the lung function and reduce

关 键 词：补肾纳气汤 支气管哮喘 缓解期 肺功能 

分 类 号：R725.6[医药卫生—儿科]