鳖甲抗肝纤维化研究进展  

Research progress of the anti-liver fibrosis of trionycis carapax

作　　者：张晔[1] 吕金朋 孙佳明[1] 张辉[1] ZHANG Ye;LYU Jinpeng;SUN Jiaming;ZHANG Hui(Changchun University of Chinese Medicine, Changchun 130117, China)

机构地区：[1]长春中医药大学,长春130117

出　　处：《吉林中医药》2018年第6期673-675,共3页Jilin Journal of Chinese Medicine

基　　金：<中国药典>名贵珍稀动物药及混伪品鉴定技术及规范应用研究(201407007-01)

摘　　要：鳖甲始载于《神农本草经》,具有滋阴潜阳、退热除蒸、软坚散结的作用。随着现代药理学研究进展,鳖甲在肝纤维化临床治疗中广泛应用,其抗肝纤维化作用得到了许多临床及实验研究的证实。通过查阅文献进行分析,发现鳖甲中寡肽类化合物是其抗肝纤维化的物质基础,鳖甲能抑制炎症反应、阻断转化生长因子信号转导途径、促进肝星状细胞凋亡、抗氧化损伤、抑制肝星状细胞的活化增殖、调控细胞外基质的产生和降解来治疗肝纤维化。Trionycis carapax was contained in the Shen Nong＇s herbal classic. It has the effect of nourishing yin and suppressing hyperactive yang, relieving fever and resolving hard lump. With the development of modern pharmacological research, trionycis carapax has been widely used in the clinical treatment of liver fibrosis, and its anti-liver fibrosis has been confirmed by many clinical and experimental studies. According to the literature review, it was found that oligopeptide compounds in trionycis carapax are the material basis of anti-liver fibrosis. Trionycis carapax can inhibit the inflammatory reaction, block TGF-β signal transduction pathways, and promote the apoptosis of the hepatic stellate cells, the antioxidant injury, inhibit the activation and proliferation of hepatic stellate cells, regulate the production and degradation of the extracellular matrix, and treat the liver fibrosis.

关 键 词：鳖甲 肝纤维化 炎症反应 转化生长因子 

分 类 号：R282[医药卫生—中药学]