动脉自旋标记成像观察不同频率声音刺激下听觉皮层的脑血流量变化  

Study on Cerebral Blood Flow of Youth Auditory Cortexunder Different Frequent Sound Stimulation Using Arterial Spin Labeling Perfusion Weighted Imaging

作　　者：张晓晶[1] 娄昕[1] 张爱莲[1] 谢林怡[2] 张秋静[2] 马林[1] 吴南洲[1] Zhang Xiaojing;Lou Xin;Zhang Ailian;Xie Linyi;Zhang Qiujing;Ma Lin;Wu Nanzhou

机构地区：[1]中国人民解放军总医院放射诊断科,北京市100853 [2]中国人民解放军总医院耳鼻咽喉头颈外科,北京市100853

出　　处：《中国病案》2018年第6期110-112,共3页Chinese Medical Record

基　　金：2015FC-TSYS-1029中国人民解放军总医院临床科研扶持基金

摘　　要：目的研究在不同频率声音刺激下大脑听觉皮层的脑血流量的变化情况。方法应用GE Discovery 750 3.0T超导磁共振扫描仪,32通道头颅线圈,收集2015年11月-2016年6月13名志愿者,所有受试者均听力正常,右利手,行常规内听道磁共振检查,全脑3D FSPGR成像以及无声音刺激下的3D ASL,右耳低频、中频、高频声音刺激下3D ASL,左耳低频、中频、高频刺激下3D ASL,双耳语音刺激下3D ASL扫描。所得数据均传输至adw4.6工作站,测量双侧听觉皮层颞叶的CBF数值。应用统计软件SPSS 17.0对所得数据进行配对t检验。结果无声音刺激下右侧及左侧颞叶CBF值分别为73.31±10.99ml/min/100g,73.10±10.72 ml/min/100g,P>0.05,差别无统计学意义;右耳低频、中频、高频声音刺激下左侧颞叶CBF值74.33±11.76ml/min/100g,76.03±10.14ml/min/100g,73.17±11.85ml/min/100g;高于相同频率刺激下右侧颞叶CBF值70.46±11.52ml/min/100g,70.92±11.03ml/min/100g,67.71±10.60ml/min/100g;P<0.05,差异有统计学意义;而左耳低频、中频、高频声音刺激下右侧颞叶CBF值78.17±9.84ml/min/100g,74.69±10.57ml/min/100g,74.51±14.79ml/min/100g,高于相同频率刺激下左侧颞叶CBF值73.53±10.07ml/min/100g,70.00±10.62ml/min/100g,70.03±15.31ml/min/100g,P<0.05,差异有统计学意义;双侧语音刺激下左、右两侧的CBF值分别为75.64±8.72ml/min/100g、75.52±8.93ml/min/100g,P>0.05,差别无统计学意义。结论 3D ASL序列可以无创性并反复进行听觉皮层的CBF值测量,并能反映不同频率声音刺激下左右双侧听皮层CBF值的差别。Objective To study the changes of cerebral blood flow（CBF） of auditory cortex under stimulation of different frequency of sound using arterial spin labeling（ASL）perfusion weighted imaging（PWI）.Methods13 young volunteers were examined using the GE Discovery 750 3.0 Teslasuperconductive MR system with 32 channels head coil from November 2015 to June 2016.All the volunteers were right-handed with normal hearing.Their internal auditory canals were scanned with 3 D-FIESTA.The whole brains were scanned with 3 D FSPGR.Non-stimulationarterial spin labeling（ASL） were acquired.Then ASL under low,middle and high frequency sound to bilateral ears were acquired respectively.After then,the ASL under stimulation to left ear and right ear separately were carried out.All the data were transferred to adw4.6 work station.CBF values of auditory cortexwere measured.Paired t-test was performedwith SPSS17.0 statistical software.Resultsthe CBF value of right temporal lobewas 73.31±10.99 ml/min/100 g with no sound stimulation.The left was 73.10±10.72 ml/min/100 g.There was no significant difference（p=0.397〉0.05）.The CBF values of left temporal lobe were74.33 ± 11.76 ml/min/100 g,76.03±10.14 ml/min/100 g and 73.17±11.85 ml/min/100 gcorresponding to stimulating right ear with low,middle and high frequency sound.The CBF of right temporal lobe were70.46±11.52 ml/min/100 g,70.92±11.03 ml/min/100 g and 67.71±10.60 ml/min/100 gcorresponding to stimulating right ear with low,middle and high frequency sound.The CBF of left temporal with stimulation to right ear were higher than those of right temporal lobe（p〈0.05）.The CBF values of righttemporal lobe were78.17±9.84 ml/min/100 g,74.69±10.57 ml/min/100 g and 74.51±14.79 ml/min/100 g with stimulation toleft ear.The CBF of lefttemporal lobewere 73.53±10.07 ml/min/100 g,70.00±10.62 ml/min/100 g and70.03±15.31 ml/min/100 g with stimulation to left ear.The CBF of right temporal lobe were higher than those of left temporal lobe（P〈0.05）.CBF of left temporal

关 键 词：动脉自旋标记 听觉皮层 脑血流量 磁共振成像 

分 类 号：R338.3[医药卫生—人体生理学] R445.2[医药卫生—基础医学]