血必净辅助血液灌流对34例急性百草枯中毒患者慢性肺损伤的预防作用分析  

Prevention effect analysis of Xuebiqing combined with blood perfusion on chronic lung injury in 68 cases with acute PQ poisoning

作　　者：史卫亮 SHI Weiliang(Emergency Department, Luoyang Central Hospital Affiliated to Zhengzhou University, Henan 471000, China)

机构地区：[1]郑州大学附属洛阳中心医院急诊科,河南471000

出　　处：《社区医学杂志》2018年第10期27-29,共3页Journal Of Community Medicine

摘　　要：目的探究血必净辅助血液灌流对急性百草枯中毒(APP)患者慢性肺损伤的预防作用。方法回顾性分析2016年1—12月收治的68例APP患者临床资料,将2016年1—6月收治的34例APP患者作为对照组,2016年7—12月收治的34例患者作为研究组。两组均行常规治疗和血液灌流,研究组在此基础上加用血必净治疗。观察两组治疗1周、2周时存活率、肺部影像学情况,评估治疗前及治疗2周后相关血清因子和呼吸参数变化情况。结果治疗1周时,两组存活率及HRCT评分对比差异均无统计学意义(均P>0.05),治疗2周时,研究组存活率高于对照组,HRCT评分低于对照组(均P<0.05);治疗2周后,两组TGF-β1水平均较治疗前升高,且研究组低于对照组(均P<0.05);两组TNF-α水平和PEEP、RR水平均较治疗前下降,且研究组低于对照组(均P<0.05);两组IL-10水平和VT水平均较治疗前上升,且研究组高于对照组(均P<0.05)。结论血必净辅助血流灌注能提高PQ中毒患者疗效,发挥减轻肺损伤程度、改善呼吸功能的作用,并在一定程度上延缓肺纤维化进程。Objective To investigate the prevention effect of Xuebiqing combined with blood perfusion on chronic lung injury in 34 cases with acute PQ poisoning.Methods Clinical data of 68 cases with APP in our hospital from January to December 2016 were retrospectively analyzed, 34 patients with APP admitted from January to June 2016 were selected as control group, 34 patients from July to December 2016 were treated as research group. The two groups were all given routine treatment and blood perfusion, the observation group was plus Xuebiqing treatment. The survival rate and imaging condition of the two groups at 1 week and 2 weeks after treatment were observed, and the changes of serum factors and respiratory parameters were evaluated before and 2 weeks after treatment.Results After 1 week, the difference of survival rate and HRCT scores between the two groups had no statistic significance（all P〈0.05）,after 2 weeks, the observation group had the higher survival rate（all P〈0.05）and lower HRCT scores（all P〈0.05）; After 2 weeks, TGF-β1 level of the two groups were all increased（all P〈0.05）, the amplification of the observation group was smaller than that in the control group（P〈0.05）, TNF-α, PEEP, RR level of the two groups were all declined after treatment（all P〈0.05）, the decreasing amplitude of the observation group was larger than that in the control group（all P〈0.05）, IL-10 and VT levels of the two groups were all increased after treatment,the amplification of the observation group was larger than that in the control group（all P〈0.05）.Conclusion Xuebiqing combined with blood perfusion can improve curative effect of patients with with acute PQ poisoning, it can relieve lung injury degree, improve respiratory function, and delay pulmonary fibrosis process.

关 键 词：血必净 血液灌流 急性百草枯中毒 慢性肺损伤 

分 类 号：R595.4[医药卫生—内科学]