厚朴酚与和厚朴酚透皮吸收的差异性  

Difference of Transdermal Absorption Between Magnolol and Honokiol

作　　者：张瑞涛[1,2] 吴振刚 赵军[2] 张旸[2] 刘雪英[4] 王庆伟[2,5] ZHANG Ruitao;WU Zhengang;ZHAO Jun;ZHANG Yang;LIU Xueying;WANG Qingwei(College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;Department of Pharmacy, Tangdu Hospital, the Fourth Military Medical University, Xi＇ an 710038, China;College of Pharmacy, North China University of Science and Technology, Tangshan 063000, China;Department of Medicine Chemistry, School of Pharmacy, the Fourth Military Medical University, Xi＇ an 710032, China;Xi＇an WenSen Pharmaceutical Technology Co., Ltd, Xi＇ an 710038, China)

机构地区：[1]陕西中医药大学药学院,咸阳712046 [2]第四军医大学唐都医院药剂科,西安710038 [3]华北理工大学药学院,唐山063000 [4]第四军医大学药学院药物化学教研室,西安710032 [5]西安文森医药科技有限公司,西安710038

出　　处：《医药导报》2018年第6期654-658,共5页Herald of Medicine

基　　金：陕西省中医药管理局课题项目(15-JC016);第四军医大学科技引擎计划成果孵化项目(2015FHB03)

摘　　要：目的研究同分异构体厚朴酚与和厚朴酚在不同促透剂条件下渗透动力学参数的差异性。方法以体外大鼠腹部皮肤作为透皮屏障,改良Franz扩散池法,乙醇-0.9%氯化钠溶液(30∶70)作为透皮吸收体系接收液,不同浓度薄荷醇、月桂氮酮、二乙二醇单乙基醚(Transcutol.P)作为促透剂,反相高效液相色谱(RP-HPLC)法测定接收液中厚朴酚与和厚朴酚浓度。结果厚朴酚与和厚朴酚在不同促透剂的作用下具有显著性差异。以月桂氮酮为促透剂,厚朴酚比和厚朴酚的透皮性能较好;薄荷醇对厚朴酚与和厚朴酚具有较为相似的促透作用;促透剂Transcutol.P对厚朴酚具有明显的抑制作用,对和厚朴酚具有较强的促透作用。结论在不同促透剂的作用下,同分异构体厚朴酚与和厚朴酚具有显著的透皮差异性,可能与两者分子结构有关。Objective To investigate the difference of osmotic kinetic parameters of magnolol and honokiol on different permeation enhancers. Methods Isolatedrat abdominal skins were served as transdermal barrier. Improved Franz diffusion cell method was applied. Ethanol-0.9%sodium chloride solution（30∶70） was served as a receiving solution transdermal absorption system,different concentrations of menthol,azone,transcutol.P as penetration enhancer. Magnolol and honokiol concentration in the receiving solution were determined by RP-HPLC. Results Magnolol and honokiol have significant differences under the action of different transdermal enhancers. When Azone served as permeation enhancer,magnolol had better transdermal property than honokiol. Menthol had a similar permeability effect on magnolol and honokiol. However,transderol. P exerted a significant inhibitory effect on magnolol while a potent permeation enhancing effect on honokiol. Conclusion Different transdermal enhancers exert different transdermal effects on magnolol and honokiol,which may be related to the different molecular structures.

关 键 词：同分异构体 厚朴酚 和厚朴酚 月桂氮酮 薄荷醇 二乙二醇单乙基醚 促透剂 

分 类 号：R969.1[医药卫生—药理学]