颈项透明层厚度在胎儿不良妊娠结局中的价值研究  

Value of Nuchal Translucency Thickness in Fetal Adverse Pregnancy Outcomes

作　　者：岳聪聪 王宏[2] 郭瑞林[1] YUE Cong-cong;WANG Hong;GUO Rui-lin(Department of Clinical laboratory, The second affiliated hospital of shaanxi university of traditional Chinese medicine, Xianyang Shaanxi 712046;Shenzhen maternal and child health care hospital, Shenzhen Guangdong 518034)

机构地区：[1]陕西中医药大学第二附属医院检验科,陕西咸阳712046 [2]深圳市妇幼保健院,广东深圳518034

出　　处：《世界最新医学信息文摘》2018年第9期31-32,34,共3页World Latest Medicine Information Electronic Version

摘　　要：目的评价颈项透明层(nuchal translucency,NT)厚度在胎儿不良妊娠结局中的预测价值。方法回顾分析2014年1月至2015年12月深圳市妇幼保健院产前唐氏筛查高风险孕妇,胎儿NT≥2.5mm并行产前诊断的281例,对胎儿染色体核型进行分析及结局随访。结果 (1)染色体核型分析:12例染色体数目异常,无结构异常,分别为10例21三体,1例18三体,1例45,XO,均终止妊娠,异常率为4.3%(12/281)。(2)在268例核型正常胎儿中,26例(9.7%)发生不良妊娠结局,分别为17例医学性引产,5例自发性流产和4例死胎。(3)不良结局共38例,发生率为13.5%。当NT范围分别为2.5~3、3~4、4~5、5~6及6~7mm时,其不良妊娠结局发生率依次为6.4%、15.9%、18.2%、57.1%及80%。(4)NT≥2.5mm筛查胎儿不良妊娠结局的灵敏度为73.1%、特异度为52.8%、阳性预测值为13.5%,阴性预测值为95.1%。结论 NT增厚显著增加了胎儿不良妊娠结局的发生,其风险随着NT增厚而增加。Objective To evaluate the predictive value of NT thickness in fetal adverse outcomes. Method From January 2014 to December 2015 in Shenzhen maternal and child health hospital, prenatal Down syndrome screening high risk pregnant women, fetal NT more than 2.5 mm parallel 281 cases of prenatal diagnosis and for fetal chromosomal karyotype of analysis and follow-up of outcome. Results（1） karyotype analysis： 12 cases of abnormal number of chromosomes, no structural abnormalities, 10 cases of trisomy 21, 1 case of trisomy 18, 1 case of 45, XO, both termination of pregnancy, the abnormal rate was 4.3%（12/281）.（2） In the 268 cases with normal karyotype fetuses,26 cases（9.7%） were adverse pregnancy outcomes, 17 cases of medical abortion, 5 cases of spontaneous abortion and 4 cases of stillbirth.（3）The adverse outcomes were 38 cases, the incidence rate was 13.5%. When the NT ranges from 2.5 to 3,3-4,4-5,5 to 6 and 6 to 7 mm, its incidence of adverse pregnancy outcomes were 6.4%, 15.9%, 18.2%, 57.1% and 80%.（4） NT≥2.5 mm screening for fetal adverse pregnancy outcomes sensitivity was 73.1%, the specificity was 52.8%, the positive predictive value was 13.5%, the negative predictive value was 95.1%. Conclusion The thickness of NT significantly increases the incidence of adverse pregnancy outcomes, and the risk increases with the increase of NT.

关 键 词：颈项透明层厚度 不良妊娠结局 超声测量 发生率 

分 类 号：R714.431[医药卫生—妇产科学]