房颤时心房组织和心肌电通道变化  

The Changes of Atrial Tissue and Myocardial Electrical Channel During Atrial Fibrillation

作　　者：程海超 葛巧云 施毅祖 吴洪海[1] CHENG Hai-chao;GE Qiao-yun;SHI Yi-zu;WU Hong-hai(Department of Clinical Medicine, Medical College of Yangzhou University, Yangzhou Jiangsu 225001)

机构地区：[1]扬州大学医学院,江苏扬州225001

出　　处：《世界最新医学信息文摘》2018年第9期55-57,共3页World Latest Medicine Information Electronic Version

基　　金：2015年江苏省大学生创新训练计划(x2015782)

摘　　要：心房颤动(房颤)是常见的室上性心律失常之一。研究发现房颤患者可出现心房的结构重构和电重构,结构重构主要表现为肌纤维溶解和肌细胞膜上缝隙链接蛋白密度降低及分布不均等;电重构则有钾离子外流增加和钙离子内流减少等变化,导致复极化速度加快、动作电位时程缩短。Atrial fibrillation（AF） is one of the common supraventricular arrhythmias.It is demonstrated that atrial remodeling and electrical remodeling appears on patients with atrial fibrillation.The structural remodeling is mainly manifested as the dissolution of muscle fibers and the density of gap junction proteins reduced,besides, which is of uneven distribution in the muscle cell membrane.The electrical remodeling includes an increase in potassium efflux and a decrease in calcium influx,causing repolarization speeding and shortening of action potential duration.

关 键 词：心房颤动 组织结构 缝隙链接蛋白 离子通道蛋白 单相动作电位 

分 类 号：R541.76[医药卫生—心血管疾病]