银蒿解热合剂抗炎镇痛解热及岗梅解热作用研究  

Antipyretic,Anti-inflammatory and Analgesic Effects of Yinhaojiere Mixture and Antipyretic Effect of Ilex Asprella

作　　者：辛晓芳[1] 林爱华[2] 梅全喜[1] Xin Xiaofang;Lin Aihua;Mei Quanxi(Hospital of Traditional Chinese Medicine of Zhongshan of Guangzhou University of Chinese Medicine, Guangdong Zhongshan 528401, China;Zhuhai Branch of Guangdong Hospital of Traditional Chinese Medicine)

机构地区：[1]广州中医药大学附属中山市中医院,广东中山528401 [2]广东省中医院珠海分院

出　　处：《中国药师》2018年第6期960-964,共5页China Pharmacist

基　　金：广东省中医药局科研基金资助项目(编号:20131078);中山市科技局重点资助项目(编号:20132A002)

摘　　要：目的:探讨银蒿解热合剂的抗炎、镇痛、解热作用及其主药岗梅的解热作用。方法:通过小鼠毛细血管通透性实验、二甲苯致小鼠耳廓肿胀实验及大鼠棉球肉芽肿实验,观察银蒿解热合剂的抗炎作用;采用小鼠扭体实验和热板法观察该合剂的镇痛作用;以干酵母致大鼠发热模型,研究银蒿解热合剂及其主药岗梅的解热作用。结果:银蒿解热合剂能明显抑制小鼠腹腔内炎性物质的渗出(P<0.05),对二甲苯致耳廓肿胀均有明显的抑制作用,对肉芽组织增生有抑制作用;能明显提高大鼠的痛阈值,尤其是对干酵母所致发热有显著的抑制作用(P<0.05)。在抗炎、镇痛和解热实验中,银蒿解热合剂中、高剂量组与吲哚美辛组比较,无显著差异(P>0.05)。在解热实验中,岗梅高剂量组,自6h起与吲哚美辛组无显著差异(P>0.05),表明主药岗梅解热作用亦较为显著。结论:以岗梅为主药的银蒿解热合剂具有很好的抗炎、解热、镇痛作用,主药岗梅有一定抗炎、镇痛作用,且其解热作用较为显著。Objective： To study the antipyretic,anti-inflammatory and analgesic effects of Yinhaojiere mixture and the antipyretic effect of Ilex asprella. Methods： The experiments of mice ear edma induced by xylene,the increase of capillary permeability by acetic acid and the sterilized cotton caused rat groin granulation tissue hyperplasia were used to study the anti-inflammatory effect of Yinhaojiere mixture; the hot-plate tests and the acetic acid writhing test were applied to research the analgesic effect of Yinhaojiere mixture.In addition,the dry yeast induced fever in rats was employed to explore the efficacy of antipyretic agents in Yinhaojiere mixture and Ilex asprella water extract. Results： Yinhaojiere mixture could obviously inhibit the inflammation of the peritoneal cavity of mice（ P 〈0. 05）. The inhibition of Yinhaojiere mixture against ear swelling induced by p-xylene was significant. Yinhaojiere mixture could significantly increase the pain threshold. Especially,Yinhaojiere mixture had significant antipyretic effect（ P〈0. 05）. In the anti-inflammatory,analgesic and antipyretic experimetns,there were no significant differences between the middle and high dose groups of Yinhaojiere mixture and indomethacin group（ P〉0. 05）. Conclusion： Yinhaojiere mixture with the Ilex asprella as the main ingredient has notable anti-inflammatory,analgesic and antipyretic effects,and Ilex asprella exhibits anti-inflammatory,analgesic effects,and its antipyretic effect is more significant.

关 键 词：银蒿解热合剂 岗梅 抗炎 镇痛 解热 

分 类 号：R285.5[医药卫生—中药学]