加味泽泻贴膏成型工艺考察  

Study on the Modeling Technology of Modified Zexie Plaster

作　　者：喻志斌[1] 李莹 王琼[3] Yu Zhibin;Li Ying;Wang Qiong(The 102nd Hospital of PLA ,Jiangsu Changzhou 213003, China;Jiangsu Dekang Medical Instrument Limited Company;Nanjing University of Chinese Medieine)

机构地区：[1]解放军第102医院,江苏常州213003 [2]江苏德康医疗器械有限公司 [3]南京中医药大学

出　　处：《中国药师》2018年第6期1130-1133,共4页China Pharmacist

摘　　要：目的:考察加味泽泻贴膏的成型工艺。方法:选取聚丙烯酸钠作为黏合剂,卡波姆作为乳化剂,甘油作为保湿剂,明胶作为赋形剂,并通过正交筛选法优选出最佳辅料配比及载药量。结果:影响因素的主次为聚丙烯酸钠>载药量>明胶>卡波姆、最佳制备工艺为A_2B_2C_2D_2,即确定最佳工艺;按照处方质量组成为:2.5%聚丙烯酸钠∶3%卡波姆∶甘油∶12%明胶∶可溶性淀粉∶载药量=70∶6∶5∶15∶3∶9。结论:按照正交试验法筛选出的最佳工艺路线,进行三批样品试验,试验样品具有很好的一致性,证明该工艺具有很好的重现性,适合工业大生产。Objective： To study the molding process of modified Zexie plaster. Methods： Sodium polyacrylate was used as the adhesive,carbomer as the emulsifier,glycerol as the humectant,and gelatin as the excipient. Orthogonal screening was applied to select the optimum formula and drug loading. Results： The significance order of the influencing factors was sodium polyacrylate 〉 drug loading 〉gelatin 〉carbomer,and the best preparation process was A2B2C2D2,which was determined as 2. 5% sodium polyacrylate ∶3%carbomer： glycerin ∶12% gelatin ∶soluble starch ∶drug loading of 70 ∶6 ∶5 ∶15 ∶3 ∶9（ mass ratio）. Conclusion： According to the optimum process route selected by orthogonal test,three batches of samples were tested,and the results showed that the process had good reproducibility,which is suitable for the industrial production.

关 键 词：加味泽泻贴膏 成型 工艺 

分 类 号：R283.62[医药卫生—中药学]